Gly-Sar (CAS 29816-01-1)
Alternate Names:
Glycyl-sarcosine
CAS Number:
29816-01-1
Molecular Weight:
146.14
Molecular Formula:
C5H10N2O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Gly-Sar, also known as glycyl-sarcosine, is a dipeptide used in research to study peptide absorption and transport mechanisms across biological membranes. It is often employed in studies investigating the functionality of peptide transporters in the intestinal tract, which are critical for understanding nutrient uptake and chemical absorption. In addition, Gly-Sar is used as a model compound in the investigation of the kinetics and dynamics of peptide transport under various physiological conditions. In cell culture systems, researchers use Gly-Sar to explore the expression and regulation of peptide transporter proteins.
Gly-Sar (CAS 29816-01-1) References
- Characterization of rPEPT2-mediated Gly-Sar transport parameters in the rat kidney proximal tubule cell line SKPT-0193 cl.2 cultured in basic growth media. | Bravo, SA., et al. 2005. Mol Pharm. 2: 98-108. PMID: 15804184
- Oligopeptides: mechanism of renal clearance depends on molecular structure. | Minami, H., et al. 1992. Am J Physiol. 263: F109-15. PMID: 1636735
- hPEPT1 is responsible for uptake and transport of Gly-Sar in the human bronchial airway epithelial cell-line Calu-3. | Søndergaard, HB., et al. 2008. Pflugers Arch. 456: 611-22. PMID: 18094991
- The proton-coupled amino acid transporter, SLC36A1 (hPAT1), transports Gly-Gly, Gly-Sar and other Gly-Gly mimetics. | Frølund, S., et al. 2010. Br J Pharmacol. 161: 589-600. PMID: 20880398
- Intestinal drug transport via the proton-coupled amino acid transporter PAT1 (SLC36A1) is inhibited by Gly-X(aa) dipeptides. | Frølund, S., et al. 2012. Mol Pharm. 9: 2761-9. PMID: 22853447
- Basolateral glycylsarcosine (Gly-Sar) transport in Caco-2 cell monolayers is pH dependent. | Berthelsen, R., et al. 2013. J Pharm Pharmacol. 65: 970-9. PMID: 23738724
- Glucose-dependent insulinotropic polypeptide regulates dipeptide absorption in mouse jejunum. | Coon, SD., et al. 2013. Am J Physiol Gastrointest Liver Physiol. 305: G678-84. PMID: 24072682
- Clearance of dipeptides from plasma: role of kidney and intestine. | Adibi, SA. 1977. Ciba Found Symp. 265-85. PMID: 244387
- Simultaneous determination of three dipeptides (JBP485, Gly-Sar and JBP923) in the cell lysates by liquid chromatography-tandem mass spectrometry: application to identify the function of the PEPT1 transfected cell. | Guo, X., et al. 2014. Biomed Chromatogr. 28: 1839-45. PMID: 24903899
- Structural Design of Oligopeptides for Intestinal Transport Model. | Hong, SM., et al. 2016. J Agric Food Chem. 64: 2072-9. PMID: 26924013
- Effect of Aging on the Absorption of Small Peptides in Spontaneously Hypertensive Rats. | Hanh, VT., et al. 2017. J Agric Food Chem. 65: 5935-5943. PMID: 28594555
- Mechanism of peptide absorption in the isolated forestomach epithelial cells of dairy cows. | Xu, Q., et al. 2019. J Sci Food Agric. 99: 100-108. PMID: 29797328
- Luminal Na+ homeostasis has an important role in intestinal peptide absorption in vivo. | Ishizuka, N., et al. 2018. Am J Physiol Gastrointest Liver Physiol. 315: G799-G809. PMID: 30138575
- Brain-transportable dipeptides across the blood-brain barrier in mice. | Tanaka, M., et al. 2019. Sci Rep. 9: 5769. PMID: 30962462
- Evaluation of PepT1 (SLC15A1) Substrate Characteristics of Therapeutic Cyclic Peptides. | Bajraktari-Sylejmani, G., et al. 2022. Pharmaceutics. 14: PMID: 36015235
Inhibitor of:
SLC15A solute carrier (SLC) group.Activator of:
PEPT1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Gly-Sar, 1 g | sc-471717 | 1 g | $112.00 | |||
Gly-Sar, 5 g | sc-471717A | 5 g | $347.00 |