Molecular structure of Gly-Phe β-naphthylamide, CAS Number: 21438-66-4
Gly-Phe β-naphthylamide (CAS 21438-66-4)
See product citations (53)
Alternate Names:
Gly-Phe β-naphthylamide is also known as Glycylphenylalanine2-naphthylamide.
Application:
Gly-Phe β-naphthylamide is a substrate for cathepsin C and inhibitor of caspase-8, useful for studying recombinant cathepsin C.
CAS Number:
21438-66-4
Purity:
≥95%
Molecular Weight:
347.41
Molecular Formula:
C21H21N3O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Gly-Phe-β-naphthylamide is a cathepsin C substrate that is described to accumulate inside lysosomes and cause their destruction. Cathepsin C cleaves the dipeptide bond of Gly-Phe-β-naphthylamide, releasing 2-naphthylamine. The release of 2-naphthylamine can be monitored spectrophotometrically, allowing for the measurement of cathepsin C activity. It has also been used to study recombinant cathepsin C. Studies report that Gly-Phe β-naphthylamide significantly inhibits the activation of caspase-8.
Gly-Phe β-naphthylamide (CAS 21438-66-4) References
- AA-861-induced Ca(2+) mobilization in Madin Darby canine kidney cells. | Huang, JK. and Jan, CR. 1999. Toxicol Appl Pharmacol. 161: 202-8. PMID: 10581214
- Caspase-8-mediated apoptosis induced by oxidative stress is independent of the intrinsic pathway and dependent on cathepsins. | Baumgartner, HK., et al. 2007. Am J Physiol Gastrointest Liver Physiol. 293: G296-307. PMID: 17431216
- Niemann-Pick disease type C1 is a sphingosine storage disease that causes deregulation of lysosomal calcium. | Lloyd-Evans, E., et al. 2008. Nat Med. 14: 1247-55. PMID: 18953351
- Expression and purification of active recombinant cathepsin C (dipeptidyl aminopeptidase I) of kuruma prawn Marsupenaeus japonicus in insect cells. | Qiu, GF., et al. 2009. J Biomed Biotechnol. 2009: 746289. PMID: 19707514
- Bone marrow-derived mesenchymal stem cells prevent the loss of Niemann-Pick type C mouse Purkinje neurons by correcting sphingolipid metabolism and increasing sphingosine-1-phosphate. | Lee, H., et al. 2010. Stem Cells. 28: 821-31. PMID: 20201063
- GTPase of the Immune-Associated Nucleotide Protein 5 Regulates the Lysosomal Calcium Compartment in T Lymphocytes. | Serrano, D., et al. 2017. Front Immunol. 8: 94. PMID: 28223986
- Transport and release of colloidal 3-mercaptopropionic acid-coated CdSe-CdS/ZnS core-multishell quantum dots in human umbilical vein endothelial cells. | Fontana, JM., et al. 2017. Int J Nanomedicine. 12: 8615-8629. PMID: 29270011
- N-acetylneuraminic acid accumulation in a buoyant lysosomal fraction of cultured fibroblasts from patients with infantile generalized N-acetylneuraminic acid storage disease. | Hildreth, J., et al. 1986. Biochem Biophys Res Commun. 139: 838-44. PMID: 2945557
- TERT enhances the survival rate of human fibroblasts under endoplasmic reticulum, Golgi apparatus, and lysosomal stresses. | Abd El-Hafeez, AA., et al. 2018. Biotechnol Lett. 40: 915-922. PMID: 29619746
- Candida albicans Hyphal Expansion Causes Phagosomal Membrane Damage and Luminal Alkalinization. | Westman, J., et al. 2018. mBio. 9: PMID: 30206168
- Lysosomal exocytosis of ATP is coupled to P2Y2 receptor in marginal cells in the stria vascular in neonatal rats. | Liu, B., et al. 2018. Cell Calcium. 76: 62-71. PMID: 30273839
- Vitamin D3 activates the autolysosomal degradation function against Helicobacter pylori through the PDIA3 receptor in gastric epithelial cells. | Hu, W., et al. 2019. Autophagy. 15: 707-725. PMID: 30612517
- Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) Induces Intracellular Ca2+ Release through the Two-Pore Channel TPC1 in Metastatic Colorectal Cancer Cells. | Faris, P., et al. 2019. Cancers (Basel). 11: PMID: 30991693
- Nicotinic acid adenine dinucleotide phosphate activates two-pore channel TPC1 to mediate lysosomal Ca2+ release in endothelial colony-forming cells. | Moccia, F., et al. 2021. J Cell Physiol. 236: 688-705. PMID: 32583526
Inhibitor of:
caspase-8, and Chemical and Peptide Caspase.Substrate of:
cathepsin C, and Enzyme.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Gly-Phe β-naphthylamide, 100 mg | sc-252858 | 100 mg | $82.00 | |||
Gly-Phe β-naphthylamide, 1 g | sc-252858A | 1 g | $673.00 |