Molecular structure of Glutathione, oxidized, CAS Number: 27025-41-8
Glutathione, oxidized (CAS 27025-41-8)
See product citations (3)
Alternate Names:
GSSG
Application:
Glutathione, oxidized is the oxidised dimeric form of glutathione that takes part in the body′s detoxification mechanisms
CAS Number:
27025-41-8
Purity:
≥95%
Molecular Weight:
612.63
Molecular Formula:
C20H32N6O12S2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Glutathione, oxidized, also known as Glutathione disulfide (GSSG), is the oxidised dimeric form of glutathione (GSH), which is a naturally occuring tripeptide that takes part in the bodies detoxification mechanisms and protects against oxidative damage. In vivo Glutathione, oxidized is reduced back to GSH via the NADPH-dependent enzyme glutathione reductase. The ratio of GSH to Glutathione, oxidized is often used to gauge the level of oxidative stress in cells, with higher concentrations of Glutathione, oxidized implying more oxidative stress.
Glutathione, oxidized (CAS 27025-41-8) References
- The changing faces of glutathione, a cellular protagonist. | Pompella, A., et al. 2003. Biochem Pharmacol. 66: 1499-503. PMID: 14555227
- Regulation of protein function by glutathionylation. | Ghezzi, P. 2005. Free Radic Res. 39: 573-80. PMID: 16036334
- Manipulating glutathione-S-transferases may prevent the development of tolerance to nitroglycerin. | Wang, L., et al. 2006. Cardiovasc Toxicol. 6: 131-44. PMID: 17303920
- MS/MS spectral tag-based annotation of non-targeted profile of plant secondary metabolites. | Matsuda, F., et al. 2009. Plant J. 57: 555-77. PMID: 18939963
- Decreased antioxidant enzyme activity and increased mitochondrial DNA damage in cellular models of Machado-Joseph disease. | Yu, YC., et al. 2009. J Neurosci Res. 87: 1884-91. PMID: 19185026
- Role of glutaredoxin-mediated protein S-glutathionylation in cellular nitroglycerin tolerance. | Tsou, PS., et al. 2009. J Pharmacol Exp Ther. 329: 649-56. PMID: 19223666
- Non-steroidal anti-inflammatory drug (NSAID) ibuprofen distresses antioxidant defense system in mussel Mytilus galloprovincialis gills. | Gonzalez-Rey, M. and Bebianno, MJ. 2011. Aquat Toxicol. 105: 264-9. PMID: 21767472
- Does non-steroidal anti-inflammatory (NSAID) ibuprofen induce antioxidant stress and endocrine disruption in mussel Mytilus galloprovincialis? | Gonzalez-Rey, M. and Bebianno, MJ. 2012. Environ Toxicol Pharmacol. 33: 361-71. PMID: 22301165
- 17β-Estradiol Directly Lowers Mitochondrial Membrane Microviscosity and Improves Bioenergetic Function in Skeletal Muscle. | Torres, MJ., et al. 2018. Cell Metab. 27: 167-179.e7. PMID: 29103922
- Pesticide risk assessment at the molecular level using honey bee cytochrome P450 enzymes: A complementary approach. | Haas, J. and Nauen, R. 2021. Environ Int. 147: 106372. PMID: 33418197
- Personalized Genome-Scale Metabolic Models Identify Targets of Redox Metabolism in Radiation-Resistant Tumors. | Lewis, JE., et al. 2021. Cell Syst. 12: 68-81.e11. PMID: 33476554
- Protective properties of Rydingia persica in reproductive complications induced by diabetes in male rats: An experimental study. | Ostovan, F., et al. 2022. Int J Reprod Biomed. 20: 123-136. PMID: 35434481
- Regulatory mechanism of glutathione reductase activity in human red cells. | Yawata, Y. and Tanaka, KR. 1974. Blood. 43: 99-109. PMID: 4809101
Inhibitor of:
ATP7B, CHIC2, G6pd2, GRXCR1, PGLS, and rcRPE.Activator of:
20S Proteasome α7, ALR, ATPBD3, COL27A1, CYB561D1, CysRS, Ero1-Lβ, FBX23, FGGY, Grx5, GRXCR2, HtrA, kynurenine, MMADHC, NUDT16, NUDT7, PDILT, PDIR, RRP9, and SPC12.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Glutathione, oxidized, 250 mg | sc-29093B | 250 mg | $57.00 | |||
Glutathione, oxidized, 1 g | sc-29093A | 1 g | $82.00 | |||
Glutathione, oxidized, 5 g | sc-29093 | 5 g | $270.00 |