Glutathione-glycine-13C2,15N1 (CAS 815610-65-2)

Glutathione, a antioxidant and detoxifying agent in the body, has shown potential in decreasing the concentrations of inflammatory cytokines (IL-6, IL-18) and neutrophils in lung tissue while increasing the level of serum Ca2+. These findings suggest that glutathione could be beneficial in the treatment of ANP. In scientific research, a stable isotope-labeled form of glutathione known as glutathione-glycine-13C2,15N is utilized to delve into its mechanism of action, biochemical and physiological effects, and potential therapeutic applications. This labeled form of glutathione allows researchers to study the metabolism and turnover of glutathione within various biological systems. It proves particularly valuable for investigating the impact of oxidative stress and inflammation on glutathione metabolism. Additionally, glutathione-glycine-13C2,15N enables the examination of how drugs and other compounds affect glutathione metabolism and turnover. Glutathione itself is a tripeptide composed of glutamic acid, cysteine, and glycine, playing a vital role in cellular antioxidant defense and detoxification processes. The metabolization of glutathione-glycine-13C2,15N in the body follows the same pathway as unlabeled glutathione. It is absorbed by cells and broken down into its constituent amino acids through the action of enzymes like gamma-glutamyltransferase and dipeptidases. By tracking the labeled amino acids, researchers can gain insights into the turnover and metabolism of glutathione within diverse biological systems.