Glutamine-rich 2 Antibody (F-4): sc-514279

Glutamine-rich 2 Antibody (F-4) is a mouse monoclonal IgG1 kappa light chain antibody that detects Glutamine-rich 2 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-Glutamine-rich 2 antibody (F-4) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Glutamine-rich 2 (F-4) monoclonal antibody recognizes a protein consisting of 1,663 amino acids, featuring a significant glutamine-rich region of nearly 400 amino acids, which plays a crucial role in mediating protein-protein interactions, thereby influencing various cellular processes such as signal transduction and gene expression. This essential protein regulates cellular functions and may contribute to disease development when dysregulated. Glutamine-rich 2 undergoes alternative splicing, resulting in three distinct isoforms, adding complexity to functional roles. Located on human chromosome 17, the Glutamine-rich 2 gene shares a region with key tumor suppressor genes, including p53 and BRCA1, which maintain genomic stability and prevent tumorigenesis. Understanding Glutamine-rich 2 interactions and functions can provide insights into cancer biology and therapeutic strategies.

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Glutamine-rich 2 Antibody (F-4) References:

1. Disease genes and chromosomes: disease maps of the human genome. Chromosome 17.  |  Gilbert, F. 1998. Genet Test. 2: 357-81. PMID: 10464617
2. Human chromosome 17 in essential hypertension.  |  Knight, J., et al. 2003. Ann Hum Genet. 67: 193-206. PMID: 12675695
3. Ring chromosome 17: phenotype variation by deletion size.  |  Shashi, V., et al. 2003. Clin Genet. 64: 361-5. PMID: 12974742
4. The breakpoint region of the most common isochromosome, i(17q), in human neoplasia is characterized by a complex genomic architecture with large, palindromic, low-copy repeats.  |  Barbouti, A., et al. 2004. Am J Hum Genet. 74: 1-10. PMID: 14666446
5. Imatinib resistance in a novel translocation der(17)t(1;17)(q25;p13) with loss of TP53 but without BCR/ABL kinase domain mutation in chronic myelogenous leukemia.  |  Yamamoto, K., et al. 2008. Cancer Genet Cytogenet. 183: 77-81. PMID: 18474303
6. The detection of TP53 mutations in chronic lymphocytic leukemia independently predicts rapid disease progression and is highly correlated with a complex aberrant karyotype.  |  Dicker, F., et al. 2009. Leukemia. 23: 117-24. PMID: 18843282
7. Novel mechanisms of gene disruption at the medulloblastoma isodicentric 17p11 breakpoint.  |  McCabe, MG., et al. 2009. Genes Chromosomes Cancer. 48: 121-31. PMID: 18973140
8. The prognostic impact of 17p (p53) deletion in 2272 adults with acute myeloid leukemia.  |  Seifert, H., et al. 2009. Leukemia. 23: 656-63. PMID: 19151774

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Glutamine-rich 2 Antibody (F-4) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-Glutamine-rich 2 Antibody (F-4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Glutamine-rich 2 Antibody (F-4) Specifications

Alternate Product Name: Glutamine-rich 2

Product Clone Name: F-4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1151-1426

Epitope Target: Glutamine-rich 2

Epitope Species: human

Product Reactivity/Detection: Glutamine-rich 2

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for Glutamine-rich 2 Antibody (F-4): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin