Molecular structure of (Glp1)-Apelin-13, CAS Number: 217082-60-5
(Glp1)-Apelin-13 (CAS 217082-60-5)
See product citations (2)
Application:
(Glp1)-Apelin-13 is a potent Apelin receptor (APJ) peptide agonist
CAS Number:
217082-60-5
Molecular Weight:
1533.81
Molecular Formula:
C69H108N22O16S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
[PYR1]-Apelin-13 is the pyro-glutamine form of the 13 amino acid polypeptide encoded by the apelin gene which yields a pre-proprotein that is processed to generate bioactive peptides consisting of 36, 17, or 13 amino acids (apelin-36, apelin-17, and apelin-13, respectively). This pyroglutamyl form of Apelin-13 has shown high activity with an EC50 = 0.30 nM. Apelin-13 (sc-351718) is an endogenous ligand of APLNR (APJ receptor), a G protein-coupled receptor (EC50 = 370 μM), that plays important roles in regulating fluid homeostasis, cardiovascular function, and insulin sensitivity. Research has also shown that Apelin-36 blocks the entry of human immunodeficiency virus into cells.
(Glp1)-Apelin-13 (CAS 217082-60-5) References
- [(125)I]-(Pyr(1))Apelin-13 is a novel radioligand for localizing the APJ orphan receptor in human and rat tissues with evidence for a vasoconstrictor role in man. | Katugampola, SD., et al. 2001. Br J Pharmacol. 132: 1255-60. PMID: 11250876
- Central and peripheral cardiovascular actions of apelin in conscious rats. | Kagiyama, S., et al. 2005. Regul Pept. 125: 55-9. PMID: 15582714
- Structural insight into G-protein coupled receptor binding by apelin. | Langelaan, DN., et al. 2009. Biochemistry. 48: 537-48. PMID: 19123778
- Preferential apelin-13 production by the proprotein convertase PCSK3 is implicated in obesity. | Shin, K., et al. 2013. FEBS Open Bio. 3: 328-33. PMID: 24251091
- Identifying structural determinants of potency for analogs of apelin-13: integration of C-terminal truncation with structure-activity. | Zhang, Y., et al. 2014. Bioorg Med Chem. 22: 2992-7. PMID: 24755525
- Angiotensin-Converting Enzyme 2 Metabolizes and Partially Inactivates Pyr-Apelin-13 and Apelin-17: Physiological Effects in the Cardiovascular System. | Wang, W., et al. 2016. Hypertension. 68: 365-77. PMID: 27217402
- Apelin-36 is protective against N-methyl-D-aspartic-acid-induced retinal ganglion cell death in the mice. | Sakamoto, K., et al. 2016. Eur J Pharmacol. 791: 213-220. PMID: 27590359
- A Systematic Exploration of Macrocyclization in Apelin-13: Impact on Binding, Signaling, Stability, and Cardiovascular Effects. | Trân, K., et al. 2018. J Med Chem. 61: 2266-2277. PMID: 29461833
- Distinct hemodynamic responses to (pyr)apelin-13 in large animal models. | Tune, JD., et al. 2020. Am J Physiol Heart Circ Physiol. 318: H747-H755. PMID: 32108522
- Intravenous Administration of Pyroglutamyl Apelin-13 Alleviates Murine Inflammatory Pain via the Kappa Opioid Receptor. | Lv, S., et al. 2020. Front Neurosci. 14: 929. PMID: 33013308
- The Regulatory Role of Apelin on the Appetite and Growth of Common Carp (Cyprinus Carpio L.). | Yan, X., et al. 2020. Animals (Basel). 10: PMID: 33233604
- Constraining the Side Chain of C-Terminal Amino Acids in Apelin-13 Greatly Increases Affinity, Modulates Signaling, and Improves the Pharmacokinetic Profile. | Trân, K., et al. 2021. J Med Chem. 64: 5345-5364. PMID: 33524256
- Prolyl Carboxypeptidase Mediates the C-Terminal Cleavage of (Pyr)-Apelin-13 in Human Umbilical Vein and Aortic Endothelial Cells. | De Hert, E., et al. 2021. Int J Mol Sci. 22: PMID: 34206648
- Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor. | Tatemoto, K., et al. 1998. Biochem Biophys Res Commun. 251: 471-6. PMID: 9792798
Inhibitor of:
OTTMUSG00000011097.Activator of:
Apelin Receptor, APLNR, CRS4C-5, FRS2, and GALR2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
(Glp1)-Apelin-13, 1 mg | sc-359030 | 1 mg | $158.00 |