(Glp1)-Apelin-13 is the pyro-glutamine form of the 13 amino acid polypeptide encoded by the apelin gene which yields a pre-proprotein that is processed to generate bioactive peptides consisting of 36, 17, or 13 amino acids (apelin-36, apelin-17, and apelin-13, respectively). This pyroglutamyl form of Apelin-13 has shown high activity with an EC50 = 0.30 nM. Apelin-13 (sc-351718) is an endogenous ligand of Apelin Receptor (APJ receptor), a G protein-coupled receptor (EC50 = 370 μM). Research has also shown that Apelin-36 blocks the entry of human immunodeficiency virus into cells. (Glp1)-Apelin-13 is an activator of Apelin Receptor.
1. Tatemoto, K., et al. 1998. Biochem. Biophys. Res. Commun. 251: 471-476. PMID: 9792798
2. Katugampola, S.D., et al. 2001. Br. J. Pharmacol. 132: 1255-1260. PMID: 11250876
3. Kagiyama, S., et al. 2005. Regul. Pept. 125: 55-59. PMID: 15582714
Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2020 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.