(Glp1)-Apelin-13 CAS: 217082-60-5
MF: C69H108N22O16S
MW: 1533.81
A potent Apelin receptor (APJ) peptide agonist.

(Glp1)-Apelin-13 (CAS 217082-60-5)

(Glp1)-Apelin-13 | CAS 217082-60-5 is rated 5.0 out of 5 by 1.
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Application: (Glp1)-Apelin-13 is a potent Apelin receptor (APJ) peptide agonist
CAS Number: 217082-60-5
Molecular Weight: 1533.81
Molecular Formula: C69H108N22O16S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

(Glp1)-Apelin-13 is the pyro-glutamine form of the 13 amino acid polypeptide encoded by the apelin gene which yields a pre-proprotein that is processed to generate bioactive peptides consisting of 36, 17, or 13 amino acids (apelin-36, apelin-17, and apelin-13, respectively). This pyroglutamyl form of Apelin-13 has shown high activity with an EC50 = 0.30 nM. Apelin-13 (sc-351718) is an endogenous ligand of Apelin Receptor (APJ receptor), a G protein-coupled receptor (EC50 = 370 μM). Research has also shown that Apelin-36 blocks the entry of human immunodeficiency virus into cells. (Glp1)-Apelin-13 is an activator of Apelin Receptor.


References

1. Tatemoto, K., et al. 1998. Biochem. Biophys. Res. Commun. 251: 471-476. PMID: 9792798
2. Katugampola, S.D., et al. 2001. Br. J. Pharmacol. 132: 1255-1260. PMID: 11250876
3. Kagiyama, S., et al. 2005. Regul. Pept. 125: 55-59. PMID: 15582714

Physical State :
Solid
Sequence :
Glp-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe
Solubility :
Soluble in water (1 mg/ml).
Storage :
Desiccate at -20° C
Density :
1.51 g/cm3 (Predicted)
Refractive Index :
n20D 1.70 (Predicted)
IC50 :
Apelin APJ receptor: EC5050 = 0.37 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
MDL Number :
MFCD01863147

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Chen Chen, D. et al. (PubMed 26391329) reported that intranasal delivery of Apelin-13 is neuro protective and promotes angiogenesis after ischemic stroke in mice. -SCBT Publication Review
Date published: 2015-02-12
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