GLP-2 Antibody (006-02): sc-57169

GLP-2 Antibody (006-02) is a mouse monoclonal IgG1 antibody that detects GLP-2 protein of human origin by enzyme-linked immunosorbent assay (ELISA). GLP-2 Antibody (006-02) is available as anti-GLP-2 antibody (006-02) without conjugation. GLP-2 protein plays a crucial role in regulating intestinal growth and function, primarily stimulating intestinal epithelial cell proliferation, which maintains gut lining integrity and promotes nutrient absorption. This function becomes especially important when intestinal barriers are compromised, helping restore and maintain gut health. GLP-2 belongs to the glucagon hormone family, alongside GLP-1, vasoactive intestinal peptide (VIP), and pituitary adenylate cyclase-activating polypeptide (PACAP). While GLP-1 regulates glucose metabolism and appetite, GLP-2′s unique role in enhancing intestinal growth highlights potential therapeutic applications in gastrointestinal disorders. GLP-2′s ability to promote epithelial cell growth makes anti-GLP-2 antibody (006-02) valuable for research into treatments for inflammatory bowel disease and short bowel syndrome.

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GLP-2 Antibody (006-02) References:

1. Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability.  |  Cani, PD., et al. 2009. Gut. 58: 1091-103. PMID: 19240062
2. The Discovery of GLP-2 and Development of Teduglutide for Short Bowel Syndrome.  |  Drucker, DJ. 2019. ACS Pharmacol Transl Sci. 2: 134-142. PMID: 32219218
3. A GLP-1/GLP-2 receptor dual agonist to treat NASH: Targeting the gut-liver axis and microbiome.  |  Kim, ER., et al. 2022. Hepatology. 75: 1523-1538. PMID: 34773257
4. GLP-1 and GLP-2 Orchestrate Intestine Integrity, Gut Microbiota, and Immune System Crosstalk.  |  Abdalqadir, N. and Adeli, K. 2022. Microorganisms. 10: PMID: 36296337
5. GLP-2 Improves Hepatic Inflammation and Fibrosis in Mdr2-/- Mice Via Activation of NR4a1/Nur77 in Hepatic Stellate Cells and Intestinal FXR Signaling.  |  Fuchs, CD., et al. 2023. Cell Mol Gastroenterol Hepatol. 16: 847-856. PMID: 37572734
6. Targeting the GLP-2 receptor in the management of obesity.  |  Pálsson, TG., et al. 2024. Peptides. 177: 171210. PMID: 38579917
7. Differential processing of proglucagon by the subtilisin-like prohormone convertases PC2 and PC3 to generate either glucagon or glucagon-like peptide.  |  Rouillé, Y., et al. 1995. J Biol Chem. 270: 26488-96. PMID: 7592866
8. Expression and functional activity of glucagon, glucagon-like peptide I, and glucose-dependent insulinotropic peptide receptors in rat pancreatic islet cells.  |  Moens, K., et al. 1996. Diabetes. 45: 257-61. PMID: 8549871
9. Glucose intolerance but normal satiety in mice with a null mutation in the glucagon-like peptide 1 receptor gene.  |  Scrocchi, LA., et al. 1996. Nat Med. 2: 1254-8. PMID: 8898756
10. Vasoactive intestinal peptide (VIP) stimulates in vitro growth of VIP-1 receptor-bearing human pancreatic adenocarcinoma-derived cells.  |  Jiang, S., et al. 1997. Cancer Res. 57: 1475-80. PMID: 9108448
11. Specific features of glycogen metabolism in the liver.  |  Bollen, M., et al. 1998. Biochem J. 336 (Pt 1): 19-31. PMID: 9806880
12. Pituitary adenylate cyclase-activating polypeptide (PACAP) 38 and PACAP27 activate common and distinct intracellular signaling pathways to stimulate growth hormone secretion from porcine somatotropes.  |  Martínez-Fuentes, AJ., et al. 1998. Endocrinology. 139: 5116-24. PMID: 9832451

The preferred Glucagon antibody is Glucagon Antibody (K79bB10): sc-57171.