Molecular structure of Gliquidone, CAS Number: 33342-05-1
Gliquidone (CAS 33342-05-1)
Alternate Names:
Gliquidonum; Beglynor
Application:
Gliquidone is an ATP-dependent K+ (KATP) channel blocker
CAS Number:
33342-05-1
Purity:
≥98%
Molecular Weight:
527.63
Molecular Formula:
C27H33N3O6S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Gliquidone is a compound that is of interest in metabolic research studies focusing on the modulation of insulin release. It is used to investigate the function of ATP-sensitive potassium channels in pancreatic beta cells, which are key regulators of insulin secretion. Research on Gliquidone also extends to studies on glucose uptake mechanisms, as understanding these pathways is essential for elucidating how cells respond to varying levels of blood glucose. Additionally, this compound is useful for probing the effects of sulfonylurea compounds on insulin receptor activity, providing insights into the complex signaling pathways that govern glucose homeostasis.
Gliquidone (CAS 33342-05-1) References
- Gliquidone contributes to improvement of type 2 diabetes mellitus management: a review of pharmacokinetic and clinical trial data. | Malaisse, WJ. 2006. Drugs R D. 7: 331-7. PMID: 17073516
- Gliquidone therapy of new-onset diabetes mellitus after kidney transplantation. | Tuerk, TR., et al. 2008. Clin Nephrol. 70: 26-32. PMID: 18793545
- Contribution of cytochrome P450 isoforms to gliquidone metabolism in rats and human. | He, F., et al. 2014. Xenobiotica. 44: 229-34. PMID: 23987740
- Pharmacokinetics and hepatic uptake of gliquidone affected by Huangqi injection. | Zhang, F., et al. 2014. Eur J Drug Metab Pharmacokinet. 39: 255-61. PMID: 24085486
- Gliquidone versus metformin: differential effects on aorta in streptozotocin induced diabetic rats. | Tan, Z., et al. 2014. Chin Med J (Engl). 127: 1298-303. PMID: 24709184
- Gliquidone Alleviates Diabetic Nephropathy by Inhibiting Notch/Snail Signaling Pathway. | Tian, H., et al. 2018. Cell Physiol Biochem. 51: 2085-2097. PMID: 30522115
- Optimization, in-vitro Release and in-vivo Evaluation of Gliquidone Nanoparticles. | Mohamed, MS., et al. 2019. AAPS PharmSciTech. 21: 35. PMID: 31879830
- Rosmarinic acid, the active component of Salvia miltiorrhizae, improves gliquidone transport by regulating the expression and function of P-gp and BCRP in Caco-2 cells. | Li, M., et al. 2020. Pharmazie. 75: 18-22. PMID: 32033628
- Gliquidone ameliorates hepatic insulin resistance in streptozotocin-induced diabetic Sur1-/- rats. | Zhang, R., et al. 2021. Eur J Pharmacol. 906: 174221. PMID: 34081903
- Fenpropathrin increases gliquidone absorption via causing damage to the integrity of intestinal barrier. | Xu, L., et al. 2022. Ecotoxicol Environ Saf. 242: 113882. PMID: 35841655
- Effects of high-altitude environment on pharmacokinetic parameters of gliquidone in rats. | Huang, L., et al. 2022. Zhejiang Da Xue Xue Bao Yi Xue Ban. 51: 389-396. PMID: 37202102
- Gliquidone, an ATP-dependent K+ channel antagonist, antagonizes morphine-induced hypermotility. | Ocaña, M., et al. 1993. Eur J Pharmacol. 239: 253-5. PMID: 8223904
- Modulation of gliquidone action by forskolin in the pancreas of normal and GK rats. | Leclercq-Meyer, V. and Malaisse, WJ. 1997. Am J Physiol. 273: E52-8. PMID: 9252479
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FXNA.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Gliquidone, 1 g | sc-295010 | 1 g | $114.00 | |||
Gliquidone, 5 g | sc-295010A | 5 g | $235.00 |