GlcNAc-1-β-4-MurNAc(OAc)5 (CAS 475502-13-7)

GlcNAc-1-β-4-MurNAc(OAc)5, also known as N-acetylglucosamine-N-acetylmuramic pentapeptide, is a key component of bacterial cell walls, particularly in Gram-positive bacteria like Staphylococcus aureus and Streptococcus pneumoniae. This complex molecule consists of N-acetylglucosamine (GlcNAc) linked to N-acetylmuramic acid (MurNAc) via a β-1,4-glycosidic bond, with five acetate groups attached to the MurNAc moiety. GlcNAc-1-β-4-MurNAc(OAc)5 serves as a substrate for enzymes involved in bacterial cell wall biosynthesis, such as peptidoglycan synthases and transpeptidases. Research on this compound focuses on elucidating the molecular mechanisms underlying bacterial cell wall synthesis and remodeling, as well as understanding how antibiotics and antimicrobial peptides target these processes to inhibit bacterial growth. Additionally, GlcNAc-1-β-4-MurNAc(OAc)5 is utilized as a tool in structural biology studies to investigate the three-dimensional architecture of bacterial cell walls and their interactions with antibiotics and host immune molecules. Furthermore, this compound serves as a target for the development of novel antibacterial agents aimed at disrupting bacterial cell wall integrity and combating antibiotic-resistant infections. Through its role in bacterial cell wall biology, GlcNAc-1-β-4-MurNAc(OAc)5 contributes to the advancement of research on antimicrobial resistance and the development of new strategies for bacterial infection control.