Glafenine hydrochloride (CAS 65513-72-6)
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Glafenine hydrochloride functions as a nonsteroidal anti-inflammatory agent (NSAI) in experimental applications. It exerts its mechanism of action by inhibiting the activity of cyclooxygenase (COX) enzymes, COX-1 and COX-2, which are involved in the synthesis of prostaglandins from arachidonic acid. By blocking the activity of these enzymes, Glafenine hydrochloride interferes with the production of prostaglandins, which are important mediators of inflammation, pain, and fever. Glafenine Hydrochloride′s mechanism of action involves the reversible binding to the active site of COX enzymes, thereby preventing the conversion of arachidonic acid to prostaglandins. As a result, Glafenine hydrochloride is able to modulate the inflammatory response and reduce pain sensation in experimental models.
Glafenine hydrochloride (CAS 65513-72-6) References
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- Correction of the Delta phe508 cystic fibrosis transmembrane conductance regulator trafficking defect by the bioavailable compound glafenine. | Robert, R., et al. 2010. Mol Pharmacol. 77: 922-30. PMID: 20200141
- Characterization of dequalinium as a XIAP antagonist that targets the BIR2 domain. | Orzáez, M., et al. 2011. Apoptosis. 16: 460-7. PMID: 21340509
- Licofelone Enhances the Efficacy of Paclitaxel in Ovarian Cancer by Reversing Drug Resistance and Tumor Stem-like Properties. | Hirst, J., et al. 2018. Cancer Res. 78: 4370-4385. PMID: 29891506
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Glafenine hydrochloride, 1 g | sc-235252 | 1 g | $27.00 |