Molecular structure of Gitoxigenin, CAS Number: 545-26-6
Gitoxigenin (CAS 545-26-6)
See product citations (1)
Alternate Names:
16β-Hydroxydigitoxigenin
Application:
Gitoxigenin is a 16β-substituted digitoxigenin
CAS Number:
545-26-6
Molecular Weight:
390.51
Molecular Formula:
C23H34O5
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Gitoxigenin is a 16beta-substituted digitoxigenin which may act as a Na+/K+-ATPase inhibitor. It is a naturally occurring diterpenoid compound found in a variety of plant species. It has been used as an inhibitor of the enzyme cyclooxygenase (COX), which is involved in the synthesis of prostaglandins and thromboxanes. Gitoxigenin has also been studied for its potential anti-inflammatory, anti-cancer, and anti-bacterial properties. Furthermore, it has demonstrated protective effects against oxidative stress and to improve cognitive function in animal models.
Gitoxigenin (CAS 545-26-6) References
- Multiresidue screen for cardiotoxins by two-dimensional thin-layer chromatography. | Holstege, DM., et al. 2000. J Agric Food Chem. 48: 60-4. PMID: 10637052
- Behaviour of cardiac glycosides and cardenolides related to digitoxigenin on sephadex LH-20. | Züllich, G., et al. 1975. J Chromatogr. 115: 117-21. PMID: 1202056
- Simultaneous determination of cardenolides by sonic spray ionization liquid chromatography-ion trap mass spectrometry--a fatal case of oleander poisoning. | Arao, T., et al. 2002. J Anal Toxicol. 26: 222-7. PMID: 12054363
- Liquid chromatography coupled on-line to flow cytometry for postcolumn homogeneous biochemical detection. | Schenk, T., et al. 2003. Anal Chem. 75: 4272-8. PMID: 14632146
- Analysis of sterol and other components present in unsaponifiable matters of mahua, sal and mango kernel oil. | Dhara, R., et al. 2010. J Oleo Sci. 59: 169-76. PMID: 20299763
- Cardenolides as oviposition deterrents to twoPieris species: Structure-activity relationships. | Huang, X. and Renwick, JA. 1994. J Chem Ecol. 20: 1039-51. PMID: 24242301
- Hydrogen peroxide-induced antioxidant activities and cardiotonic glycoside accumulation in callus cultures of endemic Digitalis species. | Cingoz, GS., et al. 2014. Plant Physiol Biochem. 82: 89-94. PMID: 24915111
- Ouabain inhibits placental sFlt1 production by repressing HSP27-dependent HIF-1α pathway. | Rana, S., et al. 2014. FASEB J. 28: 4324-34. PMID: 24970393
- Structural studies on the biosides of Digitalis lanata: bisdigitoxosides of digitoxigenin, gitoxigenin and digoxigenin. | Go, KT. and Bhandary, KK. 1989. Acta Crystallogr B. 45 (Pt 3): 306-12. PMID: 2619961
- Human cell mutants affected in the interaction of the 12 beta-OH group of cardiac glycosides with the digitalis receptor. | Gupta, RS. and Chopra, A. 1987. Biochem Pharmacol. 36: 3829-33. PMID: 2825704
- The effect of 16 beta-substitution on the structure and activity of digitoxigenin: is there an additional binding interaction with Na+,K+-ATPase? | Griffin, JF., et al. 1986. Mol Pharmacol. 29: 270-4. PMID: 3005835
- Anticancer activity and phytochemical composition of wild Gundelia tournefortii. | Abu-Lafi, S., et al. 2019. Oncol Lett. 17: 713-717. PMID: 30655821
- Structural Analysis of Diastereomeric Cardiac Glycosides and Their Genins Using Ultraperformance Liquid Chromatography-Tandem Mass Spectrometry. | Singh, Y., et al. 2021. J Am Soc Mass Spectrom. 32: 1205-1214. PMID: 33818079
- New Cardenolides from Biotransformation of Gitoxigenin by the Endophytic Fungus Alternaria eureka 1E1BL1: Characterization and Cytotoxic Activities. | Bedir, E., et al. 2021. Molecules. 26: PMID: 34069653
- Influence of 16 beta formylation on Na, K-ATPase inhibition by cardiac glycosides. | De Pover, A. and Godfraind, T. 1982. Naunyn Schmiedebergs Arch Pharmacol. 321: 135-9. PMID: 6296702
Inhibitor of:
ATPase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Gitoxigenin, 10 mg | sc-215071 | 10 mg | $342.00 | |||
Gitoxigenin, 25 mg | sc-215071A | 25 mg | $705.00 |