Molecular structure of GIT 27, CAS Number: 6501-72-0
GIT 27 (CAS 6501-72-0)
Alternate Names:
4,5-Dihydro-3-phenyl-5-isoxazoleacetic acid
Application:
GIT 27 is a compound that reduces secretion of pro-inflammatory cytokines
CAS Number:
6501-72-0
Purity:
>99%
Molecular Weight:
205.21
Molecular Formula:
C11H11NO3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Orally active immunomodulatory agent that primarily targets macrophages. Inhibits TNF-α secretion via interference of macrophage toll-like receptor (TLR) 4 and TLR 2/6 signaling pathway. Reduces secretion of pro-inflammatory cytokines IL1-β, IL-10 and IFN-γ. Antidiabetogenic and prevents IL-β and IFN-γ-induced pancreatic islet cell death in vitro.
GIT 27 (CAS 6501-72-0) References
Stosic-Grujicic et al (2007) A potent immunomodulatory compound (S,R)-3-phenyl-4,5-dihydro-5-isoxasoleacetic acid, prevents spontaneous and accelerated forms of autoimmune diabetes in NOD mice and inhibits the immunoinflammatory diabetes induced by multiple low doses of streptozotocin in CBA/H mice. J.Pharmacol.Exp.Ther. 320 1038. Stojanovic et al (2007) In vitro, ex vivo and in vivo immunopharmacological activities of the isoxazoline compound VGX-1027: Modulation of cytokine synthesis and prevention of both organ-specific and systemic autoimmune diseases in murine models. Clin.Immunol. 123 311. Mangano et al (2008) In vitro inhibition of enterobacteria-reactive CD4+CD25- T cells and suppression of immunoinflammatory colitis in mice by the novel immunomodulatory agent VGX-1027. Eur.J.Pharmacol. 586 313.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GIT 27, 10 mg | sc-203971 | 10 mg | $105.00 | |||
GIT 27, 50 mg | sc-203971A | 50 mg | $409.00 |