Molecular structure of Girard′s reagent T, CAS Number: 123-46-6
Girard′s reagent T (CAS 123-46-6)
Alternate Names:
(Carboxymethyl)trimethylammonium chloride hydrazide; (Hydrazinocarbonylmethyl)trimethylammonium chloride
CAS Number:
123-46-6
Purity:
≥98%
Molecular Weight:
167.64
Molecular Formula:
C5H14N3O•Cl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Girard′s reagent T is a chemical compound that functions as a powerful reducing agent in organic synthesis. It is used to convert aldehydes and ketones into the corresponding alcohols. The mechanism of action involves the transfer of a hydride ion from the reagent to the carbonyl group, resulting in the reduction of the functional group to an alcohol. This process occurs through a nucleophilic addition mechanism, where the hydride ion attacks the electrophilic carbon of the carbonyl group, leading to the formation of an alkoxide intermediate. Girard′s reagent T plays a role in facilitating this transformation by providing the necessary hydride source for the reduction reaction to proceed. Its ability to selectively reduce carbonyl groups may be useful in the synthesis of various organic compounds.
Girard′s reagent T (CAS 123-46-6) References
- Derivatization of small oligosaccharides prior to analysis by matrix-assisted laser desorption/ionization using glycidyltrimethylammonium chloride and Girard's reagent T. | Gouw, JW., et al. 2002. Rapid Commun Mass Spectrom. 16: 905-12. PMID: 11968119
- Derivatization with Girard reagent T combined with LC-MS/MS for the sensitive detection of 5-formyl-2'-deoxyuridine in cellular DNA. | Hong, H. and Wang, Y. 2007. Anal Chem. 79: 322-6. PMID: 17194156
- Synthesis, characterization and crystal structures of two pentagonal-bipyramidal Fe(III) complexes with dihydrazone of 2,6-diacetylpyridine and Girard's T reagent. Anticancer properties of various metal complexes of the same ligand. | Anđelković, K., et al. 2017. J Inorg Biochem. 174: 137-149. PMID: 28672143
- Synthesis and Antimicrobial Study of Novel 1-Benzylated Water-Soluble Isatin-3-hydrazones. | Bogdanov, AV., et al. 2018. Chem Biodivers. 15: e1800088. PMID: 29687663
- Sensitive and robust MALDI-TOF-MS glycomics analysis enabled by Girard's reagent T on-target derivatization (GTOD) of reducing glycans. | Zhang, Y., et al. 2019. Anal Chim Acta. 1048: 105-114. PMID: 30598139
- Application of Deep Eutectic Solvents and Ionic Liquids in the Extraction of Catechins from Tea. | Bajkacz, S., et al. 2020. Molecules. 25: PMID: 32674477
- Liquid chromatography-mass spectrometry behavior of Girard's reagent T derivatives of oxosteroid intact phase II metabolites for doping control purposes. | Kiousi, P., et al. 2021. Drug Test Anal. 13: 1822-1834. PMID: 33942526
- Effect of cationization pretreatment on the properties of cationic Eucalyptus micro/nanofibrillated cellulose. | Pedrosa, JFS., et al. 2022. Int J Biol Macromol. 201: 468-479. PMID: 35051499
- Spatial localization of β-unsaturated aldehyde markers in murine diabetic kidney tissue by mass spectrometry imaging. | Harkin, C., et al. 2022. Anal Bioanal Chem. 414: 6657-6670. PMID: 35881173
- Characterizing M-protein light chain glycosylation via mass spectrometry. | Miller, ID., et al. 2022. Clin Biochem. 109-110: 11-16. PMID: 36113628
- A comprehensive UHPLC-MS/MS method for the analysis of endogenous and exogenous steroids in serum for anti-doping purposes. | Langer, T., et al. 2022. Drug Test Anal. 14: 1904-1919. PMID: 36203263
- High-resolution ion mobility spectrometry-mass spectrometry for isomeric separation of prostanoids after Girard's reagent T derivatization. | Lamont, L., et al. 2023. Rapid Commun Mass Spectrom. 37: e9439. PMID: 36415963
- Hexavalent Chromium Removal from Industrial Wastewater by Adsorption and Reduction onto Cationic Cellulose Nanocrystals. | de Borja Ojembarrena, F., et al. 2022. Nanomaterials (Basel). 12: PMID: 36500795
- Facile one-precursor and one-pot synthesis of Girard's reagent T-based carbon dots for bacteria-resistant and anti-biofilm applications. | Yang, JL., et al. 2023. Biomed Mater. 18: PMID: 37307854
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Girard′s reagent T, 100 g | sc-235251 | 100 g | $43.00 |