Date published: 2025-11-8

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Ginsenoside F2 (CAS 62025-49-4)

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Alternate Names:
20(S)-Ginsenoside-F2; (2R,3S,4S,5R,6R)-2-(hydroxymethyl)-6-[[(3S,5R,8R,9R,10R,12R,13R,14R, 17S)-12-hydroxy-4,4,8,10,14-pentamethyl-17-[(2S)-6-methyl-2-[(2S,3R,4S, 5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyhept-5-en-2-yl]-2, 3,5,6,7,9,11,12,13,15,16, 17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]oxane-3,4,5-triol
Application:
Ginsenoside F2 is a potential inhibitor to the growth of tumors
CAS Number:
62025-49-4
Purity:
≥98%
Molecular Weight:
801.01
Molecular Formula:
C42H72O14
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Ginsenoside F2 is a bioactive compound classified among the diverse group of saponins found predominantly in Panax ginseng, a plant renowned for its various biological compounds. As one of the less polar ginsenosides, F2 is produced from the deglycosylation of more complex ginsenosides, such as Rb1, through the action of specific enzymes or acidic/bacterial hydrolysis, reflective of its dynamic transformation within the plant matrix or during extract preparation. In research contexts, ginsenoside F2 has been extensively studied for its ability to interact with cellular systems, primarily focusing on its influence on cellular mechanisms at the molecular level. Its structure allows it to interact with cell membranes and intracellular signaling pathways, which can influence gene expression and protein synthesis. Studies exploring these interactions often utilize sophisticated bioanalytical techniques, including mass spectrometry and high-performance liquid chromatography, to explain the compound′s behavior and interaction within biological systems. Additionally, research has leveraged ginsenoside F2 to explore its role in modulating cellular homeostasis and responses to environmental stresses, making it a compound of interest in fields such as plant biology and biochemistry, focusing primarily on its natural role.


Ginsenoside F2 (CAS 62025-49-4) References

  1. Ginsenoside F2 reduces hair loss by controlling apoptosis through the sterol regulatory element-binding protein cleavage activating protein and transforming growth factor-β pathways in a dihydrotestosterone-induced mouse model.  |  Shin, HS., et al. 2014. Biol Pharm Bull. 37: 755-63. PMID: 24789999
  2. Ginsenoside F2 induces the release of mediators associated with Anaphylactoid reactions.  |  Wang, L., et al. 2017. Fitoterapia. 121: 223-228. PMID: 28734737
  3. Autophagy as a molecular target for cancer treatment.  |  Kocaturk, NM., et al. 2019. Eur J Pharm Sci. 134: 116-137. PMID: 30981885
  4. Ginsenoside F2 Suppresses Adipogenesis in 3T3-L1 Cells and Obesity in Mice via the AMPK Pathway.  |  Zhou, J., et al. 2021. J Agric Food Chem. 69: 9299-9312. PMID: 34342980
  5. Therapeutic application of natural products: NAD+ metabolism as potential target.  |  Guo, C., et al. 2023. Phytomedicine. 114: 154768. PMID: 36948143
  6. Gypenoside biotransformation into ginsenoside F2 by endophytic Aspergillus niger from Gynostemma pentaphyllum.  |  Zhang, X., et al. 2023. Nat Prod Res. 1-7. PMID: 37157839
  7. Ginsenoside F2 enhances glucose metabolism by modulating insulin signal transduction in human hepatocarcinoma cells.  |  Han, S., et al. 2023. J Ginseng Res. 47: 420-428. PMID: 37252284
  8. A large-scale transcriptional analysis reveals herb-derived ginsenoside F2 suppressing hepatocellular carcinoma via inhibiting STAT3.  |  Tan, X., et al. 2023. Phytomedicine. 120: 155031. PMID: 37666060
  9. Traditional Medicine Pien Tze Huang Suppresses Colorectal Tumorigenesis Through Restoring Gut Microbiota and Metabolites.  |  Gou, H., et al. 2023. Gastroenterology. 165: 1404-1419. PMID: 37704113
  10. Ginsenoside F2-Mediated Intestinal Microbiota and Its Metabolite Propionic Acid Positively Impact the Gut-Skin Axis in Atopic Dermatitis Mice.  |  Li, D., et al. 2024. J Agric Food Chem. 72: 339-350. PMID: 38150707

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Ginsenoside F2, 1 mg

sc-391654
1 mg
$169.00

Ginsenoside F2, 5 mg

sc-391654A
5 mg
$306.00