Gimeracil is a potent inhibitor of dihydropyrimidine dehydrogenase (DPD)
CAS Number:
103766-25-2
Purity:
≥99%
Molecular Weight:
145.54
Molecular Formula:
C5H4ClNO2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Gimeracil is an antitumor agent and a potent inhibitor of dihydropyrimidine dehydrogenase (DPD).
Gimeracil (CAS 103766-25-2) References
Shirasaka, T., et al.: Cancer Res., 56, 2602 (1996), Patt, Y., et al.: J. Clin. Oncol., 22, 271 (2004), Shirao, K., et al.: Cancer, 100, 2355 (2004), Kelly, H., et al.: J. Clin. Oncol., 23, 4553(2005),
Inhibitor of:
DPYD.
Physical State :
Solid
Solubility :
Soluble in DMSO (29 mg/ml at 25° C), water (<1 mg/ml at 25° C), and ethanol (<1 mg/ml at 25° C).
Storage :
Store at 4° C
Melting Point :
>270° C (dec.) (tautomer)
Boiling Point :
~524.2° C at 760 mmHg (Predicted) (tautomer)
Density :
~1.6 g/cm3 (Predicted) (tautomer)
Refractive Index :
n20D ~1.62 (Predicted)
pK Values :
pKa: 6.52 (Predicted), pKb: 12.56 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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FAVORITES
Gimeracil, 25 mg
sc-207714
25 mg
$166.00
What is the appearance of the compound?
Asked by: two2igm05
Thank you for your question. The compound, sc-207714, is provided as a white to light yellow crystalline powder. If you have any further questions or concerns, please feel free to contact our Technical Service department by calling 800-457-3801 option 2, emailing scbt@scbt.com, or using the Live Chat function on our website.
Answered by: Tech Service 8
Date published: 2017-02-10
What is the solubility of this compound?
Asked by: two2igm05
Thank you for your question. The solubility (at 25ºC) for sc-207714 is as follows: DMSO (29 mg/mL), Water (<1 mg/mL), and Ethanol (<1 mg/mL). The designation of "<1 mg/mL" means that it is slightly soluble or insoluble. If you have any further questions, please contact our Technical Service department by calling 800-457-3801 option 2, emailing scbt@scbt.com, or using the Live Chat function on our website.
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TS from
Kawahara et alKawahara et al. (PubMed ID 25109221) used the dihydropyrimidine dehydrogenase inhibitor gimeracil as a part of S-1, an oral fluoropyrimidine derivative, for the treatment of non-small cell lung cancer. -SCBT Publication Review