Giardia lamblia 65 kDa antigen Antibody (BDI612): sc-57744

Giardia lamblia 65 kDa antigen Antibody (BDI612) is a mouse monoclonal IgG2b antibody that detects Giardia lamblia 65 kDa antigen (GL65) by western blotting (WB) and immunofluorescence (IF). Anti-GL65 antibody (BDI612) is available as the non-conjugated format. GL65 plays a crucial role in the parasite′s ability to adhere to the intestinal epithelium, which is essential for survival and pathogenicity. GL65 is located on the surface of the trophozoite form, facilitating attachment to host cells and contributing to the disruption of normal intestinal function. Understanding GL65 function is vital, as GL65 not only aids in giardiasis diagnosis but also provides insights into potential therapeutic targets for intervention. Giardia lamblia is a flagellated protozoan parasite that infects mammalian gastrointestinal tracts and causes giardiasis, a type of gastroenteritis characterized by severe diarrhea and abdominal cramps. Infection is transmitted through contaminated food or water consumption, or via contact with mammalian feces. Giardia protozoan cannot survive outside of the host environment, existing as a resilient cyst that endures in the environment for up to a month, transitioning to its active trophozoite form upon infection. Following the feeding stage, Giardia trophozoite undergoes asexual replication through longitudinal binary fission, resulting in excretion of both trophozoites and cysts through the digestive system. Trophozoite form is identifiable by its large karyosome and absence of peripheral chromatin, while cyst form is characterized by four nuclei and a retracted cytoplasm.

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Giardia lamblia 65 kDa antigen Antibody (BDI612) References:

1. Giardia lamblia -- a model organism for eukaryotic cell differentiation.  |  Svärd, SG., et al. 2003. FEMS Microbiol Lett. 218: 3-7. PMID: 12583890
2. The ultrastructure of the cyst wall of Giardia lamblia.  |  Chávez-Munguía, B., et al. 2004. J Eukaryot Microbiol. 51: 220-6. PMID: 15134259
3. Participation of the adhesive disc during karyokinesis in Giardia lamblia.  |  Benchimol, M. 2004. Biol Cell. 96: 291-301. PMID: 15145533
4. Giardia lamblia: behavior of the nuclear envelope.  |  Benchimol, M. 2004. Parasitol Res. 94: 254-264. PMID: 15349774
5. Giardia lamblia behavior under cytochalasins treatment.  |  Corrêa, G. and Benchimol, M. 2006. Parasitol Res. 98: 250-6. PMID: 16344997
6. Giardia lamblia trophozoites in gastric biopsies.  |  Misra, V., et al. 2006. Indian J Pathol Microbiol. 49: 519-23. PMID: 17183841
7. Identification and localization of cyst-specific antigens of Giardia lamblia.  |  Reiner, DS., et al. 1989. Infect Immun. 57: 963-8. PMID: 2917795
8. Lipid requirements and lipid uptake by Giardia lamblia trophozoites in culture.  |  Lujan, HD., et al. 1996. J Eukaryot Microbiol. 43: 237-42. PMID: 8640194
9. Coinfection with Giardia lamblia and Enterocytozoon bieneusi in a patient with acquired immunodeficiency syndrome and chronic diarrhea.  |  Hewan-Lowe, K., et al. 1997. Arch Pathol Lab Med. 121: 417-22. PMID: 9140314

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Giardia lamblia 65 kDa antigen Antibody (BDI612) has 0 citations in a variety of scientific publications.

Primary antibodies for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Giardia lamblia 65 kDa antigen Antibody (BDI612) Specifications

Alternate Product Name: Giardia lamblia 65 kDa antigen

Product Clone Name: BDI612

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b

Amino Acids:

Epitope Target: Giardia lamblia 65 kDa antigen

Epitope Species: Giardia lamblia

Product Reactivity/Detection: the 65 kDa antigen

Species Reactivity/Detection: Giardia lamblia

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IF

Vialing Information: Each vial contains 100 µg IgG_2b in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for Giardia lamblia 65 kDa antigen Antibody (BDI612): N/A