Molecular structure of GGACK, CAS Number: 65113-67-9
GGACK (CAS 65113-67-9)
Alternate Names:
Glutamyl-glycyl-arginine chloromethyl ketone
Application:
GGACK is a potent and irreversible inhibitor of uPA and factor Xa
CAS Number:
65113-67-9
Molecular Weight:
466.00
Molecular Formula:
C14H25ClN6O5•2HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
GGACK is a specific and potent factor Xa inhibitor, reported to decrease creatine kinase and amylase activity. Reports indicate that GGACK strongly inhibits uPA (urokinase)-induced plasmin generation and act as an anticoagulant.
GGACK (CAS 65113-67-9) References
- Evaluation of the thrombin inhibitor D-phenylalanyl-L-prolyl-L-arginine chloromethylketone (PPACK) with the factor Xa inhibitor 1,5-dansyl-L-glutamyl-L-glycyl-L-arginine chloromethylketone (GGACK) as anticoagulants for critical care clinical chemistry specimens. | Lyon, ME., et al. 1999. Clin Chim Acta. 280: 91-9. PMID: 10090527
- Fibrinogen degradation product fragment D induces endothelial cell detachment by activation of cell-mediated fibrinolysis. | Ge, M., et al. 1992. J Clin Invest. 90: 2508-16. PMID: 1281836
- A chromogenic enzymatic assay capable of detecting prourokinase-like material in plasma. | Kebabian, PR. and Henkin, J. 1992. Thromb Res. 65: 401-7. PMID: 1631804
- In vitro effects of urokinase--prevention by different inhibitors. | Oethinger, MD. and Seifried, E. 1990. Thromb Haemost. 64: 402-6. PMID: 1710833
- Functional characterisation of vizottin, the first factor Xa inhibitor purified from the leech Haementeria vizottoi. | Oliveira, DG., et al. 2012. Thromb Haemost. 108: 570-8. PMID: 22782262
- Differential reactivity of Glu-Gly-Arg-CH2Cl, a synthetic urokinase inhibitor, with single-chain and two-chain forms of urokinase-type plasminogen activator. | Lijnen, HR., et al. 1987. Eur J Biochem. 162: 351-6. PMID: 3803392
Inhibitor of:
Factor IX, Factor VII, Factor X, Trypsin, and uPA.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GGACK, 5 mg | sc-201314 | 5 mg | $315.00 | |||
GGACK, 25 mg | sc-201314A | 25 mg | $1375.00 | |||
GGACK, 100 mg | sc-201314B | 100 mg | $5000.00 |