GGA1 Antibody (D-8): sc-390420
- GGA1 Antibody (D-8) is a mouse monoclonal IgG3 κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 567-603 near the C-terminus of GGA1 of human origin
- recommended for detection of GGA1 of mouse, rat, human and avian origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine, canine, bovine and avian
- m-IgG3 BP-HRP is the preferred secondary detection reagent for GGA1 Antibody (D-8) for WB applications. This reagent is now offered in a bundle with GGA1 Antibody (D-8) (see ordering information below).
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GGA1 Antibody (D-8) is a mouse monoclonal IgG3 antibody that detects GGA1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). GGA1 is a crucial member of the GGA family of proteins, which are essential for the proper trafficking of soluble proteins from the trans-Golgi network to endosomes and lysosomes. This trafficking is vital for maintaining cellular homeostasis and ensuring that proteins reach their correct destinations within the cell. GGA1, along with GGA2 and GGA3, features a modular structure that includes an N-terminal VHS domain, a GAT domain, a hinge segment, and a C-terminal GAE domain, allowing GGA1 to interact with mannose 6-phosphate receptors and clathrin. The ability of GGA1 to recognize and bind to acidic-cluster di-leucine sequences in sorting receptors is critical for the sorting process, and GGA1′s colocalization with GGA2 on perinuclear membranes highlights GGA1′s role in cellular organization. The human GGA1 gene, located on chromosome 22, encodes a protein that shares significant sequence identity with GGA2 and GGA3, underscoring the evolutionary conservation and functional importance of GGA1 in intracellular transport mechanisms. Anti-GGA1 antibody (D-8) is an invaluable tool for researchers studying protein trafficking and cellular dynamics.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GGA1 Antibody (D-8) | sc-390420 | 200 µg/ml | $316.00 | |||
GGA1 Antibody (D-8): m-IgG3 BP-HRP Bundle | sc-550480 | 200 µg Ab; 40 µg BP | $354.00 | |||
GGA1 (D-8) Neutralizing Peptide | sc-390420 P | 100 µg/0.5 ml | $68.00 |