GGA1 Antibody (A-1): sc-390837
- GGA1 Antibody (A-1) is a mouse monoclonal IgG2b κ, cited in 1 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 563-596 near the C-terminus of GGA1 of human origin
- recommended for detection of GGA1 of mouse, rat, human and avian origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine, canine, bovine and avian
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for GGA1 Antibody (A-1). This work is in progress.
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GGA1 Antibody (A-1) is a mouse monoclonal IgG2b antibody that detects GGA1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). GGA1 is a crucial member of the GGA family of proteins, which are essential for the proper trafficking of soluble proteins from the trans-Golgi network to endosomes and lysosomes. This trafficking is vital for maintaining cellular homeostasis and ensuring that proteins reach their correct destinations for function. GGA1, along with GGA2 and GGA3, features a modular structure that includes an N-terminal VHS domain, a GAT domain, a hinge segment, and a C-terminal GAE domain. The VHS domain is particularly important as GGA1 interacts with the cytoplasmic domains of sorting receptors, recognizing specific sequences that facilitate the sorting process. GGA1 and GGA2 do not associate with each other but can colocalize on perinuclear membranes, highlighting the intricate dynamics of protein interactions within the cell. The human GGA1 gene is located on chromosome 22 and encodes a protein that shares a significant sequence identity with GGA2 and GGA3, underscoring the evolutionary conservation and functional importance of this protein family in cellular transport mechanisms.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GGA1 Antibody (A-1) | sc-390837 | 200 µg/ml | $322.00 | |||
GGA1 (A-1) Neutralizing Peptide | sc-390837 P | 100 µg/0.5 ml | $69.00 |