GFAP (h2): 293T Lysate: sc-115582

The GFAP (h2): 293T Lysate is derived from the HEK293T cell line, a human embryonic kidney cell line noted for its high transfection efficiency and extensive use in molecular and cellular biology research. This lysate contains Glial Fibrillary Acidic Protein (GFAP), an intermediate filament protein that is predominantly expressed in astrocytes, a type of glial cell in the central nervous system. GFAP is essential for maintaining the structural integrity and mechanical strength of astrocytes and plays a crucial role in astrocyte-mediated functions such as synaptic support, blood-brain barrier maintenance, and response to CNS injury. In research, the GFAP (h2): 293T Lysate is used to study the molecular mechanisms underlying glial cell function and astrocyte biology. Researchers utilize this lysate in in vitro assays to investigate the interactions between GFAP and other cytoskeletal elements, examine the regulatory pathways controlling GFAP expression and phosphorylation, and explore the role of GFAP in cellular processes such as cell migration and proliferation. This lysate is particularly valuable for analyzing the dynamics of intermediate filament assembly and disassembly, as well as the response of astrocytes to various physiological and pathological stimuli. Additionally, it aids in screening for potential modulators of GFAP activity, providing insights into the regulation of astrocyte function and the broader implications for CNS homeostasis and neurobiology.