Gemin2 Antibody (G-6): sc-166161

Gemin2 Antibody (G-6) is a mouse monoclonal IgG2a light chain antibody that detects Gemin2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Gemin2 plays a crucial role in the assembly of the survival of motor neuron (SMN) complex, which is essential for the biogenesis of spliceosomal small nuclear ribonucleoproteins (snRNPs) that are vital for pre-mRNA splicing. This process is critical for gene expression regulation and the proper functioning of the cell, as it ensures that only the correct protein-coding sequences are translated into proteins. The SMN complex, which includes Gemin2 along with other components like Gemin3, Gemin4, Gemin5, and Gemin6, is predominantly located in both the cytoplasm and the nucleus, with a significant concentration in subnuclear structures known as gems. These gems are important for the storage and assembly of snRNPs, and their dysfunction is linked to neurodegenerative diseases such as spinal muscular atrophy. Gemin2 is particularly expressed in the spinal cord and can be induced by TGFβ treatment, with elevated levels observed in certain E-cadherin negative human carcinoma cell lines. anti-Gemin2 antibody (G-6) versatility in various applications makes this product an invaluable tool for researchers studying the molecular mechanisms underlying splicing and related pathologies.

The preferred Gemin2 antibody is Gemin2 Antibody (1G9): sc-33703.