Molecular structure of Gemcitabine, CAS Number: 103882-84-4
Gemcitabine (CAS 103882-84-4)
See product citations (13)
Alternate Names:
2′,2′-Difluoro-2′-deoxycytidine
Application:
Gemcitabine is a nucleoside analog with anti-cancer properties
CAS Number:
103882-84-4
Molecular Weight:
263.20
Molecular Formula:
C9H11F2N3O4
Supplemental Information:
This is as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Gemcitabine is a nucleoside analog with anti-cancer properties. It works by replacing one of the building blocks of nucleic acids, in this case cytidine, during DNA replication. The process arrests tumor growth, as new nucleosides cannot be attached to the faulty nucleoside, resulting in apoptosis.
Gemcitabine (CAS 103882-84-4) References
- Genotoxicity of two anticancer drugs, gemcitabine and topotecan, in mouse bone marrow in vivo. | Aydemir, N. and Bilaloğlu, R. 2003. Mutat Res. 537: 43-51. PMID: 12742506
- In vitro genotoxic effects of the anticancer drug gemcitabine in human lymphocytes. | Aydemir, N., et al. 2005. Mutat Res. 582: 35-41. PMID: 15781208
- Sigma-2 receptor ligands potentiate conventional chemotherapies and improve survival in models of pancreatic adenocarcinoma. | Kashiwagi, H., et al. 2009. J Transl Med. 7: 24. PMID: 19323815
- The novel sigma-2 receptor ligand SW43 stabilizes pancreas cancer progression in combination with gemcitabine. | Hornick, JR., et al. 2010. Mol Cancer. 9: 298. PMID: 21092190
- ERK1/2 activity contributes to gemcitabine resistance in pancreatic cancer cells. | Zheng, C., et al. 2013. J Int Med Res. 41: 300-6. PMID: 23569008
- Gemcitabine-Induced Autophagy Protects Human Lung Cancer Cells from Apoptotic Death. | Wu, HM., et al. 2016. Lung. 194: 959-966. PMID: 27604425
- Metformin Inhibits Gemcitabine Induced Apoptosis in Pancreatic Cancer Cell Lines. | Zechner, D., et al. 2017. J Cancer. 8: 1744-1749. PMID: 28819370
- Gemcitabine treatment causes resistance and malignancy of pancreatic cancer stem-like cells via induction of lncRNA HOTAIR. | Wang, L., et al. 2017. Exp Ther Med. 14: 4773-4780. PMID: 29201179
- Interstitial Flow Recapitulates Gemcitabine Chemoresistance in A 3D Microfluidic Pancreatic Ductal Adenocarcinoma Model by Induction of Multidrug Resistance Proteins. | Kramer, B., et al. 2019. Int J Mol Sci. 20: PMID: 31546820
- Mitochondria as target to inhibit proliferation and induce apoptosis of cancer cells: the effects of doxycycline and gemcitabine. | Dijk, SN., et al. 2020. Sci Rep. 10: 4363. PMID: 32152409
- Synergistic effect of the herbal mixture C5E on gemcitabine treatment in PANC‑1 cells. | Pak, PJ., et al. 2021. Mol Med Rep. 23: PMID: 33760105
- m6A Methyltransferase METTL14-Mediated Upregulation of Cytidine Deaminase Promoting Gemcitabine Resistance in Pancreatic Cancer. | Zhang, C., et al. 2021. Front Oncol. 11: 696371. PMID: 34458141
- Gemcitabine and radiosensitization in human tumor cells. | Shewach, DS. and Lawrence, TS. 1996. Invest New Drugs. 14: 257-63. PMID: 8958180
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Gemcitabine, 1 g | sc-481710 | 1 g | $110.00 |