Gefitinib hydrochloride salt (CAS 184475-55-6)
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Gefitinib hydrochloride salt functions by selectively inhibiting the tyrosine kinase domain of the epidermal growth factor receptor (EGFR). EGFR is a transmembrane protein that, upon binding to its ligands, undergoes autophosphorylation of its tyrosine residues, activating downstream signaling pathways that are for cell proliferation, differentiation, and survival. By inhibiting the kinase activity of EGFR, gefitinib hydrochloride salt impedes the phosphorylation process, thereby blocking the signal transduction pathways that lead to tumor growth and proliferation in cells overexpressing EGFR. The study of gefitinib hydrochloride salt extends to understanding its effects on cellular processes such as apoptosis (programmed cell death), cell cycle arrest, and angiogenesis (formation of new blood vessels). Research into how gefitinib influences these processes can shed light on the broader implications of EGFR signaling.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Gefitinib hydrochloride salt, 1 g | sc-337854 | 1 g | $306.00 |