Gefitinib 2hydrochloride salt (CAS 184475-56-7)
Application:
Gefitinib 2hydrochloride salt is a potent and selective inhibitor of EGFR kinase
CAS Number:
184475-56-7
Molecular Weight:
519.824
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Safety Information
SDS & Certificate of Analysis
Gefitinib is an epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor and has been shown to increase phosphorylation of c-Jun NH2-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK) in HaCaT cells. Studies suggest that Gefitinib can enhance keratinocyte apoptosis via an EGFR-independent JNK-activation pathway. Research indicates that Gefitinib can induce apoptosis in several cell lines including, HaCaT cells, KG-1, P39, and primary CD34+ myeloblasts. Erlotinib (sc-202154) has similar properties to Gefitinib.
Inhibitor of:
EGFR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Gefitinib 2hydrochloride salt, 1 g | sc-337853 | 1 g | $1950.00 |