Gedunin is a naturally occurring Hsp90 inhibitor. In vitro, Gedunin induces Hsp90-dependent client protein degradation and displays antiproliferative activity (IC50 values are 3.22, 8.84 and 16.8 μM in SKBr3, MCF-7 and CaCo-2 cancer cell lines respectively). Gedunin exhibits antimalarial activity against P. falciparum (IC50 values are 0.14 and 3.1 μM in parasite development and [3H]-hypoxanthine uptake assays respectively).
1. Uddin, Shaikh J., et al., 2007. Gedunin, a limonoid from Xylocarpus granatum, inhibits the growth of CaCo-2 colon cancer cell line in vitro. Phytotherapy research : PTR. 21(8): 757-61. PMID: 17450509 2. Lee, Sung-Eun., et al., 2008. Antimalarial activity of anthothecol derived from Khaya anthotheca (Meliaceae). Phytomedicine : international journal of phytotherapy and phytopharmacology. 15(6-7): 533-5. PMID: 17913482 3. Brandt, Gary E L., et al., 2008. Gedunin, a novel hsp90 inhibitor: semisynthesis of derivatives and preliminary structure-activity relationships. Journal of medicinal chemistry. 51(20): 6495-502. PMID: 18816111
Soluble in DMSO (10 mM), and ethanol (10 mM).
Store at 4° C
n20D 1.58 (Predicted)
α20/D +60.8°, c = 1 in methanol
P. falciparum in parasite development : IC50 = 0.14 µM; P. falciparum in [3H]-hypoxanthine uptake assays : IC50 = 3.1 µM; SKBr3: IC50 = 3.22 µM; MCF-7: IC50 = 8.84 µM; CaCo-2 : IC50 = 16.8 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
what is the LD50 value or IC 50 value of Gedunin in Rat or in any animal model? I have purchased your product for my research purpose.
Asked by: suchi
Thank you for your question. We are not able to provide a reference or source for LD50 or IC50 values in an animal model. We do provide IC 50 values in cancer cell lines in our product “description” tab, along with references for these studies.
Answered by: Technical Support
Date published: 2019-04-07
What is the appearance of the compound?
Asked by: two2igm05
Thank you for your question. Gedunin, sc-203967, is a white solid.
Answered by: Chemical Support 4
Date published: 2017-03-09
Bonjour, il me faudrait la disponibilté de la genudine, les frais de portet le délai pour 06130 Grasse - France
Asked by: Francis Hadji Minaglou
Merci pour votre requête. Veuillez contacter notre Centre de Support Européen à l'adresse [email protected] pour plus d'informations quant à la disponibilité de ce produit et les frais de port pour votre adresse.
Thank you for your question. Please contact our European Support Office at [email protected] for additional information about the availability and shipping fees of this product to your country.
To place an order using RMB or to ship to mainland China, please visit www.scbio.cn