Gedunin CAS: 2753-30-2
MF: C28H34O7
MW: 482.57
An Hsp90 inhibitor.

Gedunin (CAS 2753-30-2)

Gedunin | CAS 2753-30-2 is rated 5.0 out of 5 by 1.
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Synonym: (1S,3aS,4aR,4bS,5R,6aR,10aR,10bR,12aS)-5-(Acetyloxy)-1-(3-furanyl)-1,5,6,6a,7,10a,10b,11,12,12a,decahydro-4b,7,7,10a,12a,-pentamethyloxireno[c]phenanthro[1,2-d]pyran-3,8(3aH,4bH)-dione
Application: An Hsp90 inhibitor
CAS Number: 2753-30-2
Purity: >98%
Molecular Weight: 482.57
Molecular Formula: C28H34O7
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

Gedunin is a naturally occurring Hsp90 inhibitor. In vitro, Gedunin induces Hsp90-dependent client protein degradation and displays antiproliferative activity (IC50 values are 3.22, 8.84 and 16.8 μM in SKBr3, MCF-7 and CaCo-2 cancer cell lines respectively). Gedunin exhibits antimalarial activity against P. falciparum (IC50 values are 0.14 and 3.1 μM in parasite development and [3H]-hypoxanthine uptake assays respectively).


References

1. Uddin, Shaikh J., et al., 2007. Gedunin, a limonoid from Xylocarpus granatum, inhibits the growth of CaCo-2 colon cancer cell line in vitro. Phytotherapy research : PTR. 21(8): 757-61. PMID: 17450509
2. Lee, Sung-Eun., et al., 2008. Antimalarial activity of anthothecol derived from Khaya anthotheca (Meliaceae). Phytomedicine : international journal of phytotherapy and phytopharmacology. 15(6-7): 533-5. PMID: 17913482
3. Brandt, Gary E L., et al., 2008. Gedunin, a novel hsp90 inhibitor: semisynthesis of derivatives and preliminary structure-activity relationships. Journal of medicinal chemistry. 51(20): 6495-502. PMID: 18816111

Appearance :
Crystalline
Physical State :
Solid
Solubility :
Soluble in DMSO (10 mM), and ethanol (10 mM).
Storage :
Store at 4° C
Refractive Index :
n20D 1.58 (Predicted)
Optical Activity :
α20/D +60.8°, c = 1 in methanol
IC50 :
P. falciparum in parasite development : IC50 = 0.14 µM; P. falciparum in [3H]-hypoxanthine uptake assays : IC50 = 3.1 µM; SKBr3: IC50 = 3.22 µM; MCF-7: IC50 = 8.84 µM; CaCo-2 : IC50 = 16.8 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
LK9275200
PubChem CID :
5701985
SMILES :
CC(=O)O[[email protected]@H]1CC2[[email protected]](C=CC(=O)C2(C)C)(C3[[email protected]@]1([[email protected]]45[[email protected]](O4)C(=O)O[[email protected]]([[email protected]@]5(CC3)C)C6=COC=C6)C)C

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Certificate of Analysis

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Gedunin  Product Citations

See how others have used Gedunin. Click on the entry to view the PubMed entry .

Citations 1 to 4 of 4 total

PMID: # 31127528  Tom, S.|Rane, A.|Katewa, AS.|Chamoli, M.|Matsumoto, RR.|Andersen, JK.|Chinta, SJ.| et al. 2019. Mol. Neurobiol.

PMID: # 29194514  McCourt, JL. et al. 2018. Hum. Mol. Genet. 27: 451-462.

PMID: # 28680880  Tharmarajah, L. et al. 2017. Biomed Res Int. 2017: 2413197.

PMID: # 26284260  Edwards, MR. et al. 2015. ACS infectious diseases. 1: 380-387.

Citations 1 to 4 of 4 total

what is the LD50 value or IC 50 value of Gedunin in Rat or in any animal model? I have purchased your product for my research purpose.

Asked by: suchi
Thank you for your question. We are not able to provide a reference or source for LD50 or IC50 values in an animal model. We do provide IC 50 values in cancer cell lines in our product “description” tab, along with references for these studies.
Answered by: Technical Support
Date published: 2019-01-26

What is the appearance of the compound?

Asked by: two2igm05
Thank you for your question. Gedunin, sc-203967, is a white solid.
Answered by: Chemical Support 4
Date published: 2017-03-09

Bonjour, il me faudrait la disponibilté de la genudine, les frais de portet le délai pour 06130 Grasse - France

Asked by: Francis Hadji Minaglou
Merci pour votre requête. Veuillez contacter notre Centre de Support Européen à l'adresse [email protected] pour plus d'informations quant à la disponibilité de ce produit et les frais de port pour votre adresse. Thank you for your question. Please contact our European Support Office at [email protected] for additional information about the availability and shipping fees of this product to your country.
Answered by: Technical Support Europe
Date published: 2017-07-31
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Rated 5 out of 5 by from Borges PV; et al Borges PV; et al. (PubMed ID: 26330549) Determined that Gedunin blocks the formation of TLR4/MD-2/LPS complex and acts as a competitive inhibitor of LPS. -SCBT Publication Review
Date published: 2015-02-21
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