Molecular structure of GEA 3162, CAS Number: 144575-47-3
GEA 3162 (CAS 144575-47-3)
Alternate Names:
1,2,3,4-Oxatriazolium, 5-amino-3-(3,4-dichlorophenyl)-, chloride
Application:
GEA 3162 is a water-soluble nitric oxide donor
CAS Number:
144575-47-3
Purity:
≥97%
Molecular Weight:
267.5
Molecular Formula:
C7H4Cl2N4O•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
GEA 3162 is a water-soluble nitric oxide donor and potent inhibitor of ADP-induced platelet aggregation in platelet rich plasma (PRP). GEA 3162 stimulates cGMP production in platelets, granulocytes, and polymorphonuclear leukocytes and also acts as a vasodepressant.
GEA 3162 (CAS 144575-47-3) References
- Effects of nitric oxide donors GEA 3162 and SIN-1 on ethanol-induced gastric ulceration in rats. | Asmawi, MZ., et al. 1999. Eur J Pharmacol. 378: 123-7. PMID: 10478572
- Ca(2+) entry activated by S-nitrosylation. Relationship to store-operated ca(2+) entry. | Ma, HT., et al. 1999. J Biol Chem. 274: 35318-24. PMID: 10585397
- GEA 3162 decomposes to co-generate nitric oxide and superoxide and induces apoptosis in human neutrophils via a peroxynitrite-dependent mechanism. | Taylor, EL., et al. 2004. Br J Pharmacol. 143: 179-85. PMID: 15289284
- Flow cytometric evaluation of human neutrophil apoptosis during nitric oxide generation in vitro: the role of exogenous antioxidants. | Sulowska, Z., et al. 2005. Mediators Inflamm. 2005: 81-7. PMID: 16030390
- GEA3162, a nitric oxide-releasing agent, activates non-store-operated Ca2+ entry and inhibits store-operated Ca2+ entry pathways in neutrophils through thiol oxidation. | Hsu, MF., et al. 2006. Eur J Pharmacol. 535: 43-52. PMID: 16540105
- Pharmacology of mesoionic oxatriazole derivatives in blood, cardiovascular and respiratory systems. | Corell, T., et al. 1994. Pol J Pharmacol. 46: 553-66. PMID: 7542520
- Mesoionic oxatriazole derivatives--a new group of NO-donors. | Karup, G., et al. 1994. Pol J Pharmacol. 46: 541-52. PMID: 7620516
- Nitric oxide donor GEA 3162 inhibits endothelial cell-mediated oxidation of low density lipoprotein. | Malo-Ranta, U., et al. 1994. FEBS Lett. 337: 179-83. PMID: 8287973
- Inhibition by nitric oxide-donors of human polymorphonuclear leucocyte functions. | Moilanen, E., et al. 1993. Br J Pharmacol. 109: 852-8. PMID: 8395300
- Effect of a new nitric oxide donor on the biomechanical performance of the isolated ischaemic rat heart. | Szekeres, M., et al. 1997. Acta Physiol Scand. 161: 55-61. PMID: 9381950
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GEA 3162, 10 mg | sc-203055 | 10 mg | $68.00 | |||
GEA 3162, 50 mg | sc-203055A | 50 mg | $287.00 |