Gcap14 Antibody (C-4): sc-393718

Gcap14 Antibody (C-4) is a mouse monoclonal IgM antibody that detects Gcap14 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-Gcap14 antibody (C-4) is available as the non-conjugated form. Gcap14, also known as FAM190B (family with sequence similarity 190, member B), is an 834 amino acid protein that exists as three alternatively spliced isoforms and belongs to the FAM190 family. Gcap14 plays a crucial role in cellular processes, particularly in the regulation of cell cycle progression and apoptosis, making Gcap14 essential for maintaining normal cellular function and preventing uncontrolled cell growth. The gene encoding Gcap14 is located on human chromosome 10q23.1, which spans nearly 135 million base pairs and encodes approximately 1,200 genes, including those involved in various critical biological functions. Notably, defects in genes on chromosome 10 have been linked to several genetic disorders, underscoring the importance of Gcap14 in health and disease. Anti-Gcap14 antibody (C-4) serves as an invaluable tool for scientists studying the intricate roles of Gcap14 in various biological contexts.

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Gcap14 Antibody (C-4) References:

1. Report of the third international workshop on human chromosome 10 mapping and sequencing 1999.  |  Deloukas, P., et al. 2000. Cytogenet Cell Genet. 90: 1-12. PMID: 11060438
2. Chromosome 10.  |  Gilbert, F. 2001. Genet Test. 5: 69-82. PMID: 11336406
3. Molecular cell biology of Charcot-Marie-Tooth disease.  |  Berger, P., et al. 2002. Neurogenetics. 4: 1-15. PMID: 12030326
4. Cowden syndrome-affected patients with PTEN promoter mutations demonstrate abnormal protein translation.  |  Teresi, RE., et al. 2007. Am J Hum Genet. 81: 756-67. PMID: 17847000
5. First report of ovarian dysgerminoma in Cowden syndrome with germline PTEN mutation and PTEN-related 10q loss of tumor heterozygosity.  |  Cho, MY., et al. 2008. Am J Surg Pathol. 32: 1258-64. PMID: 18594467
6. PTEN: a new guardian of the genome.  |  Yin, Y. and Shen, WH. 2008. Oncogene. 27: 5443-53. PMID: 18794879
7. Mutation update for the CSB/ERCC6 and CSA/ERCC8 genes involved in Cockayne syndrome.  |  Laugel, V., et al. 2010. Hum Mutat. 31: 113-26. PMID: 19894250
8. Jackson-Weiss and Crouzon syndromes are allelic with mutations in fibroblast growth factor receptor 2.  |  Jabs, EW., et al. 1994. Nat Genet. 8: 275-9. PMID: 7874170

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Gcap14 Antibody (C-4) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-Gcap14 Antibody (C-4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Gcap14 Antibody (C-4) Specifications

Alternate Product Name: Gcap14

Product Clone Name: C-4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 786-817

Epitope Target: Gcap14

Epitope Species: human

Product Reactivity/Detection: Gcap14

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for Gcap14 Antibody (C-4): P: Blocking Peptide