GBR 12783 dihydrochloride (CAS 67469-57-2)
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GBR 12783 dihydrochloride is a compound that functions as a potent and selective inhibitor of the dopamine transporter (DAT). It acts by binding to the DAT and preventing the reuptake of dopamine from the synaptic cleft into the presynaptic neuron. This mechanism of action leads to an increase in dopamine levels in the synaptic cleft, ultimately enhancing dopaminergic neurotransmission. GBR 12783 dihydrochloride achieves this by competitively inhibiting the binding of dopamine to the transporter, thereby prolonging the presence of dopamine in the synaptic cleft. GBR 12783 dihydrochloride ′s ability to modulate dopamine levels makes it useful for studying the role of dopamine in various physiological and pathological processes. Its selective action on the dopamine transporter makes it a useful chemical for investigating the specific functions of dopamine in the central nervous system.
GBR 12783 dihydrochloride (CAS 67469-57-2) References
- Recovery of dopamine neuronal transporter but lack of change of its mRNA in substantia nigra after inactivation by a new irreversible inhibitor characterized in vitro and ex vivo in the rat. | Régo, JC., et al. 1999. Br J Pharmacol. 128: 51-60. PMID: 10498834
- Chronic GBR 12909 administration differentially alters prodynorphin gene expression compared to cocaine. | Romualdi, P., et al. 2001. Eur J Pharmacol. 413: 207-12. PMID: 11226394
- In vivo labelling of the neuronal dopamine uptake complex in the mouse striatum by [3H]GBR 12783. | Vaugeois, JM., et al. 1992. Eur J Pharmacol. 210: 77-84. PMID: 1350989
- Cloning, pharmacological characterization, and chromosome assignment of the human dopamine transporter. | Giros, B., et al. 1992. Mol Pharmacol. 42: 383-90. PMID: 1406597
- One-step purification of the serotonin transporter located at the human platelet plasma membrane. | Launay, JM., et al. 1992. J Biol Chem. 267: 11344-51. PMID: 1534559
- The antidepressant-like effect of Hypericum caprifoliatum Cham & Schlecht (Guttiferae) on forced swimming test results from an inhibition of neuronal monoamine uptake. | Viana, A., et al. 2005. Neuropharmacology. 49: 1042-52. PMID: 16040063
- Antidepressant-like effect of hyperfoliatin, a polyisoprenylated phloroglucinol derivative from Hypericum perfoliatum (Clusiaceae) is associated with an inhibition of neuronal monoamines uptake. | do Rego, JC., et al. 2007. Eur J Pharmacol. 569: 197-203. PMID: 17574234
- Appearance of a stereotyped apomorphine-induced climbing in unresponsive DBA2 mice after subchronic manipulations of brain dopamine transmission. | Duterte-Boucher, D. and Costentin, J. 1989. Psychopharmacology (Berl). 98: 56-60. PMID: 2543019
- Age-dependent dopamine transporter dysfunction and Serine129 phospho-α-synuclein overload in G2019S LRRK2 mice. | Longo, F., et al. 2017. Acta Neuropathol Commun. 5: 22. PMID: 28292328
- Repeated exposure to 3,4-methylenedioxypyrovalerone and cocaine produces locomotor sensitization with minimal effects on brain monoamines. | Kohler, RJ., et al. 2018. Neuropharmacology. 134: 22-27. PMID: 29042316
- Dopamine Transporter, PhosphoSerine129 α-Synuclein and α-Synuclein Levels in Aged LRRK2 G2019S Knock-In and Knock-Out Mice. | Domenicale, C., et al. 2022. Biomedicines. 10: PMID: 35453631
- GBR 12783, a potent and selective inhibitor of dopamine uptake: biochemical studies in vivo and ex vivo. | Bonnet, JJ. and Costentin, J. 1986. Eur J Pharmacol. 121: 199-209. PMID: 3754516
- Evidence for the sequential formation of two complexes between an uptake inhibitor, GBR 12783 [1-[2-(diphenylmethoxy)ethyl]-4-(3-phenyl-2-propenyl)piperazine], and the neuronal transporter of dopamine. | Do-Régo, JC., et al. 1999. J Neurochem. 72: 396-404. PMID: 9886093
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GBR 12783 dihydrochloride, 10 mg | sc-203587 | 10 mg | $188.00 | |||
GBR 12783 dihydrochloride, 50 mg | sc-203587A | 50 mg | $676.00 |