GATAD2B Antibody (ZZ-9): sc-101052

GATAD2B Antibody (ZZ-9) is a mouse monoclonal IgG2a kappa light chain antibody that detects GATAD2B protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-GATAD2B antibody (ZZ-9) is available as a non-conjugated format. GATAD2B, also known as P66beta, is a 593 amino acid protein characterized by the presence of a GATA-type zinc finger, which is crucial for DNA binding and transcriptional regulation. GATAD2B (ZZ-9) antibody recognizes nuclear protein that forms discrete foci and is expressed in various tissues, indicating fundamental roles in cellular processes. GATAD2B functions primarily as a transcriptional repressor, interacting with methyl-CpG-binding protein MBD3, a key component of the MeCP1 complex. The MeCP1 complex is essential for repressing transcription through mechanisms such as histone deacetylation and nucleosomal remodeling, which lead to chromatin condensation and transcriptional silencing. By recruiting MBD3 to specific nuclear regions, GATAD2B plays a pivotal role in mediating transcriptional repression, which is particularly relevant in cancer, as expression has been observed in various cancer cell lines, suggesting potential involvement in tumorigenesis.

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GATAD2B Antibody (ZZ-9) References:

1. Identification and functional characterization of the p66/p68 components of the MeCP1 complex.  |  Feng, Q., et al. 2002. Mol Cell Biol. 22: 536-46. PMID: 11756549
2. Two highly related p66 proteins comprise a new family of potent transcriptional repressors interacting with MBD2 and MBD3.  |  Brackertz, M., et al. 2002. J Biol Chem. 277: 40958-66. PMID: 12183469
3. p66alpha and p66beta of the Mi-2/NuRD complex mediate MBD2 and histone interaction.  |  Brackertz, M., et al. 2006. Nucleic Acids Res. 34: 397-406. PMID: 16415179
4. SUMO modification enhances p66-mediated transcriptional repression of the Mi-2/NuRD complex.  |  Gong, Z., et al. 2006. Mol Cell Biol. 26: 4519-28. PMID: 16738318
5. Mutants in the mouse NuRD/Mi2 component P66alpha are embryonic lethal.  |  Marino, S. and Nusse, R. 2007. PLoS One. 2: e519. PMID: 17565372
6. 1q21.3 deletion involving GATAD2B: An emerging recurrent microdeletion syndrome.  |  Tim-Aroon, T., et al. 2017. Am J Med Genet A. 173: 766-770. PMID: 28211977
7. GATAD2B-related intellectual disability due to parental mosaicism and review of literature.  |  Kaur, P., et al. 2019. Clin Dysmorphol. 28: 190-194. PMID: 31205050
8. GATAD2B Gene Microdeletion Causing Intellectual Disability Autosomal Dominant Type 18: Case Report and Review of the Literature.  |  Trubnykova, M., et al. 2019. Mol Syndromol. 10: 186-194. PMID: 31602190
9. GATAD2B-associated neurodevelopmental disorder (GAND): clinical and molecular insights into a NuRD-related disorder.  |  Shieh, C., et al. 2020. Genet Med. 22: 878-888. PMID: 31949314
10. Clinical and molecular description of 19 patients with GATAD2B-Associated Neurodevelopmental Disorder (GAND).  |  Vera, G., et al. 2020. Eur J Med Genet. 63: 104004. PMID: 32688057
11. GATAD2B is required for pre-implantation embryonic development by regulating zygotic genome activation.  |  Lin, Y., et al. 2024. Cell Prolif. 57: e13647. PMID: 38605678
12. The GATAD2B-NuRD complex drives DNA:RNA hybrid-dependent chromatin boundary formation upon DNA damage.  |  Liu, Z., et al. 2024. EMBO J. 43: 2453-2485. PMID: 38719994

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-GATAD2B Antibody (ZZ-9) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-GATAD2B Antibody (ZZ-9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

GATAD2B Antibody (ZZ-9) Specifications

Alternate Product Name: GATAD2B

Product Clone Name: ZZ-9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 3-111

Epitope Target: GATAD2B

Epitope Species: human

Product Reactivity/Detection: GATAD2B

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for GATAD2B Antibody (ZZ-9): N/A