GATAD1 Antibody (GATA9A1D3): sc-81092

GATAD1 Antibody (GATA9A1D3) is a mouse monoclonal IgG2b antibody that detects GATAD1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). Anti-GATAD1 antibody (GATA9A1D3) is available as a non-conjugated format. GATAD1, also known as GATA zinc finger domain-containing protein 1 or ODAG (ocular development-associated gene protein), is a 269 amino acid protein crucial for early ocular development, particularly in the formation of the lens and its surrounding structures. GATAD1 is predominantly expressed in postnatal eye tissue, highlighting a significant role in transforming ocular tissues into a functional eye. GATAD1 contains a GATA-type zinc finger that serves as a DNA-binding domain, which is essential for regulatory functions in gene expression. GATAD1 expression decreases significantly after the early stages of development, indicating temporal importance in ocular morphogenesis. GATAD1 gene expression has been found to be amplified in certain cancerous cells, suggesting a potential involvement in carcinogenesis, making GATAD1 a protein of interest in both developmental biology and cancer research.

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GATAD1 Antibody (GATA9A1D3) References:

1. Ocular development-associated gene (ODAG), a novel gene highly expressed in ocular development.  |  Tsuruga, T., et al. 2002. Gene. 290: 125-30. PMID: 12062807
2. Identification of PFTAIRE protein kinase 1, a novel cell division cycle-2 related gene, in the motile phenotype of hepatocellular carcinoma cells.  |  Pang, EY., et al. 2007. Hepatology. 46: 436-45. PMID: 17559150
3. Amplification at 7q22 targets cyclin-dependent kinase 6 in T-cell lymphoma.  |  Nagel, S., et al. 2008. Leukemia. 22: 387-92. PMID: 17989712
4. Egfr amplification specific gene expression in phyllodes tumours of the breast.  |  Agelopoulos, K., et al. 2007. Cell Oncol. 29: 443-51. PMID: 18032821
5. GATAD1 gene amplification promotes glioma malignancy by directly regulating CCND1 transcription.  |  Zhang, S., et al. 2019. Cancer Med. 8: 5242-5253. PMID: 31286678
6. Effect of GATAD1 regulating the SRRM2 gene on recurrence of thyroid tumor and its molecular mechanism.  |  Wang, X., et al. 2022. Gland Surg. 11: 1897-1907. PMID: 36654960
7. CRISPR screen identifies GATAD1 as a synthetic lethal target with CDK4/6 inhibitors in estrogen receptor-positive breast cancer.  |  Liu, W., et al. 2023. Med Oncol. 40: 267. PMID: 37567972
8. Knockdown of circ-Gatad1 alleviates LPS induced HK2 cell injury via targeting miR-22-3p/TRPM7 axis in septic acute kidney.  |  Zhang, P., et al. 2024. BMC Nephrol. 25: 79. PMID: 38443846
9. Pathogenic mutations of human phosphorylation sites affect protein-protein interactions.  |  Rrustemi, T., et al. 2024. Nat Commun. 15: 3146. PMID: 38605029
10. Correction: Knockdown of circ-Gatad1 alleviates LPS induced HK2 cell injury via targeting miR-22- 3p/TRPM7 axis in septic acute kidney.  |  Zhang, P., et al. 2024. BMC Nephrol. 25: 147. PMID: 38664673
11. GATAD1 is involved in sphingosylphosphorylcholine-attenuated myocardial ischemia-reperfusion injury by modulating myocardial fatty acid oxidation and glucose oxidation.  |  Cai, Y., et al. 2024. Free Radic Biol Med. 227: 166-178. PMID: 39626862
12. Loss of GATAD1 in cardiomyocyte does not cause cardiomyopathy in mice.  |  Pang, J., et al. 2024. J Mol Histol. 56: 33. PMID: 39641830

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-GATAD1 Antibody (GATA9A1D3) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-GATAD1 Antibody (GATA9A1D3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

GATAD1 Antibody (GATA9A1D3) Specifications

Alternate Product Name: GATAD1

Product Clone Name: GATA9A1D3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b

Amino Acids:

Epitope Target: GATAD1

Epitope Species: human

Product Reactivity/Detection: GATAD1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, FCM

Vialing Information: Each vial contains 100 µg IgG_2b in 1.0 ml of PBS with < 0.1% sodium azide and 1.0% stabilizer protein

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for GATAD1 Antibody (GATA9A1D3): N/A