Gastrin-1, rat (CAS 81123-06-0)

Gastrin-1, rat, is a peptide hormone primarily produced in the stomach and plays a crucial role in regulating gastric acid secretion and gastric motility. Research on Gastrin-1, rat, has predominantly focused on its physiological functions and its implications in gastrointestinal physiology. Mechanistically, Gastrin-1 binds to and activates the cholecystokinin B receptor (CCKBR), a G-protein coupled receptor expressed on parietal cells in the gastric mucosa. Activation of CCKBR by Gastrin-1 leads to intracellular signaling cascades that stimulate the secretion of gastric acid and pepsinogen, promoting the digestive processes in the stomach. Additionally, Gastrin-1 has been implicated in the regulation of gastric mucosal growth and repair through its interactions with various growth factors and receptors. In research settings, Gastrin-1, rat, has been utilized as a tool to study the molecular mechanisms underlying gastric acid secretion, mucosal protection, and the pathophysiology of gastrointestinal disorders. Furthermore, Gastrin-1 analogs and inhibitors have been developed based on its structure, and these compounds have been investigated for their potential applications in conditions such as peptic ulcer disease and gastrinoma. Overall, Gastrin-1, rat, serves as a valuable research tool in gastrointestinal physiology, offering insights into the complex regulatory pathways involved in gastric function and mucosal homeostasis.