Molecular structure of GANT 58, CAS Number: 64048-12-0
GANT 58 (CAS 64048-12-0)
See product citations (3)
Alternate Names:
GANT 58 is also known as 2,3,4,5-Tetra(4-pyridyl)thiophene and NSC 75503.
Application:
GANT 58 is a cell-permeable hedgehog signaling pathway inhibitor of GLI1-induced transcriptional activity.
CAS Number:
64048-12-0
Purity:
≥98%
Molecular Weight:
392.48
Molecular Formula:
C24H16N4S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Hh/Gli Antagonist, GANT58 is a cell-permeable tetrapyridinylthiophene compound that acts as downstream Hedgehog (Hh) pathway blocker and targets Gli-mediated gene transactivation (IC50 ~ 5 7µM in SAG-stimulated Shh-L2 cells). Hh/Gli Antagonist, GANT58 has beem shown to reduce cellular mRNA levels of hedgehog target genes, Gli1, Hip1, Ptch, and inhibit Gli-dependent tumor growth in vitro. Its action appears to be hedgehog pathway-selective, downstream of Smo and Sufu, but does not seem to interfere with Gli DNA binding. Hh/Gli Antagonist, GANT58 is an inhibitor of hedgehog.
GANT 58 (CAS 64048-12-0) References
- Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists. | Lauth, M., et al. 2007. Proc Natl Acad Sci U S A. 104: 8455-60. PMID: 17494766
- GLI1 is a direct transcriptional target of EWS-FLI1 oncoprotein. | Beauchamp, E., et al. 2009. J Biol Chem. 284: 9074-82. PMID: 19189974
- GLI1 is a central mediator of EWS/FLI1 signaling in Ewing tumors. | Joo, J., et al. 2009. PLoS One. 4: e7608. PMID: 19859563
- Small-molecule modulators of the Sonic Hedgehog signaling pathway. | Stanton, BZ. and Peng, LF. 2010. Mol Biosyst. 6: 44-54. PMID: 20024066
- Molecular pathways: the role of primary cilia in cancer progression and therapeutics with a focus on Hedgehog signaling. | Hassounah, NB., et al. 2012. Clin Cancer Res. 18: 2429-35. PMID: 22415315
- Inhibition of hedgehog signaling by GANT58 induces apoptosis and shows synergistic antitumor activity with AKT inhibitor in acute T cell leukemia cells. | Hou, X., et al. 2014. Biochimie. 101: 50-9. PMID: 24394624
- Canonical hedgehog signalling regulates hepatic stellate cell-mediated angiogenesis in liver fibrosis. | Zhang, F., et al. 2017. Br J Pharmacol. 174: 409-423. PMID: 28052321
- Hedgehog pathway plays a vital role in HIV-induced epithelial-mesenchymal transition of podocyte. | Lan, X., et al. 2017. Exp Cell Res. 352: 193-201. PMID: 28159470
- Regulation of angiogenic behaviors by oxytocin receptor through Gli1-indcued transcription of HIF-1α in human umbilical vein endothelial cells. | Zhu, J., et al. 2017. Biomed Pharmacother. 90: 928-934. PMID: 28445928
- Glioma-Associated Oncogene Homolog Inhibitors Have the Potential of Suppressing Cancer Stem Cells of Breast Cancer. | Jeng, KS., et al. 2018. Int J Mol Sci. 19: PMID: 29734730
- Sonic hedgehog pathway activation regulates cervical cancer stem cell characteristics during epithelial to mesenchymal transition. | Sharma, A., et al. 2019. J Cell Physiol. 234: 15726-15741. PMID: 30714153
- Hedgehog Inhibitors Suppress Osteoclastogenesis in In Vitro Cultures, and Deletion of Smo in Macrophage/Osteoclast Lineage Prevents Age-Related Bone Loss. | Kohara, Y., et al. 2020. Int J Mol Sci. 21: PMID: 32326611
- Knockdown of E-cadherin induces cancer stem-cell-like phenotype and drug resistance in cervical cancer cells. | Sharma, A., et al. 2021. Biochem Cell Biol. 99: 587-595. PMID: 33677985
- Hedgehog Signalling Contributes to Trauma-Induced Tendon Heterotopic Ossification and Regulates Osteogenesis through Antioxidant Pathway in Tendon-Derived Stem Cells. | Li, G., et al. 2022. Antioxidants (Basel). 11: PMID: 36421451
Inhibitor of:
GLI-1, GLI-2, and hedgehog.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GANT 58, 10 mg | sc-358832 | 10 mg | $265.00 | |||
GANT 58, 50 mg | sc-358832A | 50 mg | $837.00 | |||
GANT 58, 100 mg | sc-358832B | 100 mg | $1150.00 | |||
GANT 58, 500 mg | sc-358832C | 500 mg | $4687.00 |