Ganglioside GT1b trisodium salt (CAS 59247-13-1)
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Ganglioside GT1b trisodium salt is primarily used in neuroscientific research due to its role in cell-to-cell communication and interaction with neuronal receptors. This complex glycosphingolipid is utilized in studies exploring the mechanisms of synaptic transmission and neural development, as well as in the investigation of neurotrophic factors that support neuron survival and growth. Its involvement in the formation and maintenance of nerve cell membranes makes it useful for understanding the structural dynamics of the nervous system. Researchers also employ GT1b as a model to study the binding properties of toxins, viruses, and antibodies to gangliosides, which is for elucidating the pathogenesis of certain neurodegenerative conditions. Furthermore, in the realm of biochemistry, it is used to investigate the intricate processes of cell differentiation and apoptosis, as gangliosides have been shown to play a role in these vital cellular events.
Ganglioside GT1b trisodium salt (CAS 59247-13-1) References
- Ganglioside GT1B and melatonin inhibit brain mitochondrial DNA damage and seizures induced by kainic acid in mice. | Yamamoto, HA. and Mohanan, PV. 2003. Brain Res. 964: 100-6. PMID: 12573517
- In vivo and in vitro effects of melatonin or ganglioside GT1B on L-cysteine-induced brain mitochondrial DNA damage in mice. | Yamamoto, HA. and Mohanan, PV. 2003. Toxicol Sci. 73: 416-22. PMID: 12700404
- Delayed increase of Ca2+ influx elicited by glutamate: role in neuronal death. | Manev, H., et al. 1989. Mol Pharmacol. 36: 106-12. PMID: 2568579
- A dual-ligand fusion peptide improves the brain-neuron targeting of nanocarriers in Alzheimer's disease mice. | Guo, Q., et al. 2020. J Control Release. 320: 347-362. PMID: 31978446
- Reengineering the specificity of the highly selective Clostridium botulinum protease via directed evolution. | Dyer, RP., et al. 2022. Sci Rep. 12: 9956. PMID: 35705606
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ganglioside GT1b trisodium salt, 1 mg | sc-202629 | 1 mg | $160.00 | |||
Ganglioside GT1b trisodium salt, 5 mg | sc-202629A | 5 mg | $470.00 |