Ganglioside GM1 sodium salt (CAS 37758-47-7)
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Ganglioside GM1 sodium salt is a specific and only receptor for cholera toxin which facilitates the toxin′s transmembrane movement. Cells which lack Ganglioside GM1 can be toxin-resistant, further proving the role of this receptor in the cholera toxicity mechanism. Experiments have shown Ganglioside GM1 and bis(monoacylglycerol)phosphate (BMP) mixtures to spontaneously form small spherical vesicles of homogenous size in an energy independent manner. In addition, this receptor has been found to significantly decrease hydrogen peroxide-induced reactive oxygen species accumulation in PC-12 (sc-2250) cells. It has been shown that the reduction in reactive oxygen species is due to activation of protein kinase perceiving signal from this enzyme and tyrosine kinase Trk-receptors. We supply the Ganglioside GM1 sodium salt form.
Ganglioside GM1 sodium salt (CAS 37758-47-7) References
- [Role of tyrosine kinase of Trk-receptors in realization of antioxidant effect of ganglioside GM1 in PC12 cells]. | Vlasova, IuA., et al. 2009. Zh Evol Biokhim Fiziol. 45: 465-71. PMID: 19886192
- Bis(monoacylglycero)phosphate and ganglioside GM1 spontaneously form small homogeneous vesicles at specific concentrations. | Chebukati, JN., et al. 2010. Biochem Biophys Res Commun. 394: 509-14. PMID: 20206128
- The relationship between the concentration of ganglioside GM1 and antitumor activity of edelfosine--the Langmuir monolayer study. | Hac-Wydro, K. and Dynarowicz-Łatka, P. 2010. Colloids Surf B Biointerfaces. 81: 385-8. PMID: 20692132
- Role of membrane gangliosides in the binding and action of bacterial toxins. | Fishman, PH. 1982. J Membr Biol. 69: 85-97. PMID: 6752418
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ganglioside GM1 sodium salt, 1 mg | sc-202624 | 1 mg | $77.00 | |||
Ganglioside GM1 sodium salt, 5 mg | sc-202624A | 5 mg | $278.00 | |||
Ganglioside GM1 sodium salt, 10 mg | sc-202624B | 10 mg | $530.00 | |||
Ganglioside GM1 sodium salt, 100 mg | sc-202624C | 100 mg | $4590.00 | |||
Ganglioside GM1 sodium salt, 1 g | sc-202624D | 1 g | $26874.00 |