Date published: 2025-12-18

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Ganglioside GM1, Asialo (CAS 71012-19-6)

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Alternate Names:
ASIALOGANGLIOSIDE-GM1
Application:
Ganglioside GM1, Asialo is a sialic acid-containing glycolipid known to modulate cell signal transduction
CAS Number:
71012-19-6
Molecular Weight:
1255.56
Molecular Formula:
C62H114N2O23
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Ganglioside GM1, Asialo, also known as Asialo GM1, a naturally occurring glycolipid part of the ganglioside family in mammalian cell plasma membranes, has garnered attention for its role in research and potential in various scientific applications. This glycolipid, devoid of sialic acid, is instrumental in modulating cell signal transduction, serving as a key marker for identifying cell types and antigens, and is in forming vesicles without the need for protein templates. Its involvement in the immune response, particularly in the production of interferon-gamma by T cells in certain immune-related conditions, underscores its importance in studying adaptive immunity mechanisms. Ganglioside GM1, Asialo′s utility extends to examining cell membrane structures and functions, contributing to the advancement of drug development and delivery methods. It also plays a role in cancer research due to its anti-tumor properties. The glycolipid functions by attaching to specific receptors on cell membranes, triggering a cascade of signaling pathways that influence hormone and protein synthesis, cell growth, and differentiation, highlighting its multifaceted significance in scientific investigations.


Ganglioside GM1, Asialo (CAS 71012-19-6) References

  1. Nonclinical safety evaluation of Escherichia coli heat-labile toxin mucosal adjuvant as a component of a nasal influenza vaccine.  |  Zurbriggen, R., et al. 2003. Expert Rev Vaccines. 2: 295-304. PMID: 12899579
  2. Interferon-gamma: an overview of signals, mechanisms and functions.  |  Schroder, K., et al. 2004. J Leukoc Biol. 75: 163-89. PMID: 14525967
  3. T cells from patients with Guillain-Barré syndrome produce interferon-gamma in response to stimulation with the ganglioside GM1.  |  McCombe, PA. and Csurhes, PA. 2010. J Clin Neurosci. 17: 537-8. PMID: 20093028
  4. Bis(monoacylglycero)phosphate and ganglioside GM1 spontaneously form small homogeneous vesicles at specific concentrations.  |  Chebukati, JN., et al. 2010. Biochem Biophys Res Commun. 394: 509-14. PMID: 20206128
  5. Association study between an outbreak of Guillain-Barre syndrome in Jilin, China, and preceding Campylobacter jejuni infection.  |  Zhang, M., et al. 2010. Foodborne Pathog Dis. 7: 913-9. PMID: 20455754
  6. Binding of Vibrio cholera toxin and the heat-labile enterotoxin of Escherichia coli to GM1, derivatives of GM1, and nonlipid oligosaccharide polyvalent ligands.  |  Schengrund, CL. and Ringler, NJ. 1989. J Biol Chem. 264: 13233-7. PMID: 2666416
  7. Brain Cholesterol Metabolism and Its Defects: Linkage to Neurodegenerative Diseases and Synaptic Dysfunction.  |  Petrov, AM., et al. 2016. Acta Naturae. 8: 58-73. PMID: 27099785
  8. Infectious Entry and Neutralization of Pathogenic JC Polyomaviruses.  |  Geoghegan, EM., et al. 2017. Cell Rep. 21: 1169-1179. PMID: 29091757
  9. Sulfated glycoconjugate receptors for the Bordetella pertussis adhesin filamentous hemagglutinin (FHA) and mapping of the heparin-binding domain on FHA.  |  Hannah, JH., et al. 1994. Infect Immun. 62: 5010-9. PMID: 7927782
  10. Mutations in the lysosomal beta-galactosidase gene that cause the adult form of GM1 gangliosidosis.  |  Chakraborty, S., et al. 1994. Am J Hum Genet. 54: 1004-13. PMID: 8198123

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Ganglioside GM1, Asialo, 1 mg

sc-202625
1 mg
$335.00

Ganglioside GM1, Asialo, 10 mg

sc-202625A
10 mg
$2047.00

Ganglioside GM1, Asialo, 100 mg

sc-202625B
100 mg
$15000.00

1. Is HPLC analysis possible? 2. What is the purity?

Asked by: flos2096
Thank you for your question. We are unable to provide HPLC analysis at this time. The most recent lot has a purity of ≥ 98 % (TLC). Purity is lot specific. Actual purity may vary depending on which lot you have. Please contact our Technical Service Department for further support.
Answered by: Technical Support
Date published: 2020-04-08

hello is this asialo or sialic acid-containing ganglioside?

Asked by: pank007
Thank you for your question. Ganglioside GM1, Asialo: sc-202625 has an alternate name that is Asialoganglioside-GM1. If this does not answer your question, please contact our Technical Service Department for more information. Please call us toll-free at (800) 457-3801 option 2, e-mail <scbt@scbt.com>, or use the live chat on our website.
Answered by: Technical Support
Date published: 2017-10-13
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Rated 5 out of 5 by from McCombeMcCombe, PA. et al. (PubMed 20093028) reported that T cells from subjects with Guillain-Barr syndrome produce interferon-gamma in response to stimulation with Ganglioside GM1, Asialo. -SCBT Publication Review
Date published: 2015-04-28
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Ganglioside GM1, Asialo is rated 5.0 out of 5 by 1.
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