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Ganciclovir Sodium Salt (CAS 107910-75-8)

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Alternate Names:
2-amino-1,9-dihydro-9-[[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl]-6h-purin-6-one sodium salt
Application:
Ganciclovir Sodium Salt is an inhibitor of the Herpesvirus family
CAS Number:
107910-75-8
Purity:
≥98%
Molecular Weight:
277.21
Molecular Formula:
C9H12N5O4•Na
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Ganciclovir Sodium Salt is a compound widely used in the field of virology research due to its activity in relation to viruses belonging to the herpes family. In the laboratory, it is utilized to study viral replication mechanisms, as it targets viral DNA polymerases, thereby providing insights into the inhibition of viral DNA synthesis. This compound is particularly useful in molecular biology for the selective induction of cell death in genetically modified cells that express viral thymidine kinase, an approach used to investigate cell lineage and function in complex tissues. Additionally, its role in the study of antiviral resistance is significant, as it helps researchers understand how mutations in viral genes contribute to the evasion of antiviral agents. In the area of cell biology, Ganciclovir Sodium Salt is used to probe the effects of viral infection on cellular processes, offering a clearer picture of how viral pathogens hijack host cell machinery for replication and spread.


Ganciclovir Sodium Salt (CAS 107910-75-8) References

  1. Experimental transmission of Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8) to SCID-hu Thy/Liv mice.  |  Dittmer, D., et al. 1999. J Exp Med. 190: 1857-68. PMID: 10601360
  2. Ganciclovir-loaded albumin nanoparticles: characterization and in vitro release properties.  |  Merodio, M., et al. 2001. Eur J Pharm Sci. 12: 251-9. PMID: 11113644
  3. Biodegradable PLGA microspheres loaded with ganciclovir for intraocular administration. Encapsulation technique, in vitro release profiles, and sterilization process.  |  Herrero-Vanrell, R., et al. 2000. Pharm Res. 17: 1323-8. PMID: 11145241
  4. Biodegradable microspheres for vitreoretinal drug delivery.  |  Herrero-Vanrell, R. and Refojo, MF. 2001. Adv Drug Deliv Rev. 52: 5-16. PMID: 11672871
  5. Ocular disposition and tolerance of ganciclovir-loaded albumin nanoparticles after intravitreal injection in rats.  |  Merodio, M., et al. 2002. Biomaterials. 23: 1587-94. PMID: 11922464
  6. Stability of ganciclovir sodium in 5% dextrose injection and in 0.9% sodium chloride injection over 35 days.  |  Parasrampuria, J., et al. 1992. Am J Hosp Pharm. 49: 116-8. PMID: 1570851
  7. Stability of ganciclovir sodium (DHPG sodium) in 5% dextrose or 0.9% sodium chloride injections.  |  Visor, GC., et al. 1986. Am J Hosp Pharm. 43: 2810-2. PMID: 3492139
  8. Ganciclovir-loaded polymer microspheres in rabbit eyes inoculated with human cytomegalovirus.  |  Veloso, AA., et al. 1997. Invest Ophthalmol Vis Sci. 38: 665-75. PMID: 9071221

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Ganciclovir Sodium Salt, 10 mg

sc-394139
10 mg
$210.00

Ganciclovir Sodium Salt, 25 mg

sc-394139B
25 mg
$369.00

Ganciclovir Sodium Salt, 100 mg

sc-394139A
100 mg
$655.00

Ganciclovir Sodium Salt, 500 mg

sc-394139C
500 mg
$1438.00

Ganciclovir Sodium Salt, 1 g

sc-394139D
1 g
$2060.00