Ganciclovir-d5 (CAS 1189966-73-1)
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Ganciclovir-d5 is an antiviral, labelled Ganciclovir. Ganciclovir itself is a synthetic analogue of 2′-deoxy-guanosine, which inhibits viral DNA replication by competitively inhibiting viral DNA polymerases and by incorporation into viral DNA, leading to premature chain termination. It is especially effective against cytomegalovirus (CMV), a herpes virus. The introduction of deuterium into ganciclovir to produce Ganciclovir-d5 offers several advantages in research applications. Deuterium bonds are stronger than hydrogen bonds, which can reduce the rate of metabolic degradation of the molecule. Ganciclovir-d5 can be used as an internal standard in mass spectrometry-based analyses, improving the accuracy and reliability of quantifying ganciclovir concentrations in biological samples.
Ganciclovir-d5 (CAS 1189966-73-1) References
- Prediction of Oral Drug Absorption in Rats from In Vitro Data. | Akiyama, Y., et al. 2023. Pharm Res. 40: 359-373. PMID: 35169960
- Detection of Ganciclovir-Resistant Cytomegalovirus in a Prospective Cohort of Kidney Transplant Recipients Receiving Subtherapeutic Valganciclovir Prophylaxis. | Wong, DD., et al. 2022. Microbiol Spectr. 10: e0268421. PMID: 35658598
- Therapeutic Drug Monitoring of Ganciclovir in Cytomegalovirus-Infected Patients with solid organ Transplants and Its Correlation to Efficacy and Toxicity. | van der Wekken-Pas, LC., et al. 2022. Ther Drug Monit.. PMID: 36730727
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ganciclovir-d5, 1 mg | sc-218563 | 1 mg | $394.00 |