γD-crystallin Antibody (SB-18): sc-100697

γD-crystallin Antibody (SB-18) is a mouse monoclonal IgG1 kappa light chain antibody that detects γD-crystallin of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-γD-crystallin antibody (SB-18) is available as the non-conjugated format. γD-crystallin plays a crucial role in maintaining the transparency and refractive index of the vertebrate eye lens, which is essential for proper vision. γD-crystallin (SB-18) monoclonal antibody is part of the crystallin family, which is vital for lens structure and function, and exists primarily as a monomer, lacking connecting peptides and terminal extensions found in other crystallins. The unique structure of γD-crystallin, characterized by seven homologous motifs, allows effective contribution to the lens′s optical properties. Alterations in the expression or structure of γD-crystallin can lead to cataract formation, highlighting its significance in ocular health. Anti-γD-crystallin antibody (SB-18) serves as an invaluable tool for researchers studying lens biology, cataractogenesis, and the molecular mechanisms underlying vision.

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γD-crystallin Antibody (SB-18) References:

1. Crystal cataracts: human genetic cataract caused by protein crystallization.  |  Pande, A., et al. 2001. Proc Natl Acad Sci U S A. 98: 6116-20. PMID: 11371638
2. Lens crystallins and their microbial homologs: structure, stability, and function.  |  Jaenicke, R. and Slingsby, C. 2001. Crit Rev Biochem Mol Biol. 36: 435-99. PMID: 11724156
3. Expression and regulation of alpha-, beta-, and gamma-crystallins in mammalian lens epithelial cells.  |  Wang, X., et al. 2004. Invest Ophthalmol Vis Sci. 45: 3608-19. PMID: 15452068
4. Regulation of expression within a gene family. The case of the rat gammaB- and gammaD-crystallin promoters.  |  Klok, EJ., et al. 1998. J Biol Chem. 273: 17206-15. PMID: 9642290
5. Purification of gamma-crystallin from human lenses by acetone precipitation method.  |  Srivastava, OP. and Srivastava, K. 1998. Curr Eye Res. 17: 1074-81. PMID: 9846626
6. Degradation of gamma D- and gamma s-crystallins in human lenses.  |  Srivastava, OP. and Srivastava, K. 1998. Biochem Biophys Res Commun. 253: 288-94. PMID: 9878530
7. Progressive juvenile-onset punctate cataracts caused by mutation of the gammaD-crystallin gene.  |  Stephan, DA., et al. 1999. Proc Natl Acad Sci U S A. 96: 1008-12. PMID: 9927684

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-γD-crystallin Antibody (SB-18) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-γD-crystallin Antibody (SB-18) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

γD-crystallin Antibody (SB-18) Specifications

Alternate Product Name: γD-crystallin

Product Clone Name: SB-18

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 75-175

Epitope Target: γD-crystallin

Epitope Species: human

Product Reactivity/Detection: γD-crystallin

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for γD-crystallin Antibody (SB-18): N/A