γ2 Tubulin Antibody (SP-30): sc-134228

γ2 Tubulin Antibody (SP-30) is a mouse monoclonal IgG2a kappa light chain antibody that detects γ2 Tubulin in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-γ2 Tubulin antibody (SP-30) is available in a non-conjugated form, allowing for versatile experimental use. γ2 Tubulin, also known as TUBG2, is a crucial member of the tubulin family, consisting of 451 amino acids, and plays a significant role in the assembly of microtubules, particularly in the minus-end nucleation process. This function is vital for maintaining the structural integrity of the cytoskeleton, which is essential for various cellular processes, including cell division, intracellular transport, and the maintenance of cell shape. γ2 Tubulin monoclonal antibody (SP-30) is particularly important in studying cellular organization and signaling, as disruptions in microtubule dynamics can lead to severe consequences, including impaired cell motility and division, which are often observed in cancerous cells. The gene encoding γ2 Tubulin is located on human chromosome 17, a region that is also home to critical tumor suppressor genes such as p53 and BRCA1, both of which are integral to maintaining genomic stability and preventing tumorigenesis.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

γ2 Tubulin Antibody (SP-30) References:

1. Paxillin localizes to the lymphocyte microtubule organizing center and associates with the microtubule cytoskeleton.  |  Herreros, L., et al. 2000. J Biol Chem. 275: 26436-40. PMID: 10840040
2. The gamma-tubulin gene family in humans.  |  Wise, DO., et al. 2000. Genomics. 67: 164-70. PMID: 10903841
3. Gamma-tubulin complexes and microtubule nucleation.  |  Moritz, M. and Agard, DA. 2001. Curr Opin Struct Biol. 11: 174-81. PMID: 11297925
4. Gene knockout analysis of two gamma-tubulin isoforms in mice.  |  Yuba-Kubo, A., et al. 2005. Dev Biol. 282: 361-73. PMID: 15893303
5. Gamma-tubulin complexes and microtubule organization.  |  Raynaud-Messina, B. and Merdes, A. 2007. Curr Opin Cell Biol. 19: 24-30. PMID: 17178454
6. Regulation of microtubule nucleation mediated by γ-tubulin complexes.  |  Sulimenko, V., et al. 2017. Protoplasma. 254: 1187-1199. PMID: 28074286
7. Assembly and regulation of γ-tubulin complexes.  |  Farache, D., et al. 2018. Open Biol. 8: PMID: 29514869
8. Multifaceted modes of γ-tubulin complex recruitment and microtubule nucleation at mitotic centrosomes.  |  Zhu, Z., et al. 2023. J Cell Biol. 222: PMID: 37698931
9. Transition of human γ-tubulin ring complex into a closed conformation during microtubule nucleation.  |  Brito, C., et al. 2024. Science. 383: 870-876. PMID: 38305685
10. Structure of the γ-tubulin ring complex-capped microtubule.  |  Aher, A., et al. 2024. Nat Struct Mol Biol. 31: 1124-1133. PMID: 38609661
11. Analysis of the gamma-tubulin sequences: implications for the functional properties of gamma-tubulin.  |  Burns, RG. 1995. J Cell Sci. 108 (Pt 6): 2123-30. PMID: 7673333
12. Characterization of the human homologue of the yeast spc98p and its association with gamma-tubulin.  |  Tassin, AM., et al. 1998. J Cell Biol. 141: 689-701. PMID: 9566969

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-γ2 Tubulin Antibody (SP-30) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-γ2 Tubulin Antibody (SP-30) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

γ2 Tubulin Antibody (SP-30) Specifications

Alternate Product Name: gamma Tubulin

Product Clone Name: SP-30

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 1-101

Epitope Target: γ2 Tubulin

Epitope Species: human

Product Reactivity/Detection: γ2 Tubulin

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for γ2 Tubulin Antibody (SP-30): N/A