Date published: 2025-10-14

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γ-Tocopherol (CAS 54-28-4)

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Alternate Names:
(R,R,R)-γ-Tocopherol; 7,8-Dimethyltocol
Application:
γ-Tocopherol is a naturally occurring tocopherol
CAS Number:
54-28-4
Purity:
≥96%
Molecular Weight:
416.68
Molecular Formula:
C28H48O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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γ-Tocopherol is a form of tocopherol with methyl groups at positions 7 and 8 of the chroman-6-ol core. It is predominantly present in maize oil and soybean oils. This compound serves as a plant metabolite, food antioxidant, and algal metabolite. Additionally, it is classified as a vitamin E and a tocopherol.


γ-Tocopherol (CAS 54-28-4) References

  1. Effects of various tocopherol-containing diets on tocopherol secretion into bile.  |  Yamashita, K., et al. 2000. Lipids. 35: 163-70. PMID: 10757547
  2. The effect of gamma-tocopherol administration on alpha-tocopherol levels and metabolism in humans.  |  Yoshikawa, S., et al. 2005. Eur J Clin Nutr. 59: 900-5. PMID: 15928686
  3. Distribution of serum concentrations of alpha-tocopherol and gamma-tocopherol in the US population.  |  Ford, ES., et al. 2006. Am J Clin Nutr. 84: 375-83. PMID: 16895886
  4. Gamma-tocopherol-enriched mixed tocopherol diet inhibits prostate carcinogenesis in TRAMP mice.  |  Barve, A., et al. 2009. Int J Cancer. 124: 1693-9. PMID: 19115203
  5. Supplemental and highly elevated tocopherol doses differentially regulate allergic inflammation: reversibility of α-tocopherol and γ-tocopherol's effects.  |  McCary, CA., et al. 2011. J Immunol. 186: 3674-85. PMID: 21317387
  6. α-Tocopherol does not accelerate depletion of γ-tocopherol and tocotrienol or excretion of their metabolites in rats.  |  Uchida, T., et al. 2013. Lipids. 48: 687-95. PMID: 23700248
  7. The vitamin E isoforms α-tocopherol and γ-tocopherol have opposite associations with spirometric parameters: the CARDIA study.  |  Marchese, ME., et al. 2014. Respir Res. 15: 31. PMID: 24629024
  8. Gamma-tocopherol enhances apoptotic effects of lovastatin in human colorectal carcinoma cell line (HT29).  |  Rezaei, M., et al. 2014. Nutr Cancer. 66: 1386-93. PMID: 25296535
  9. α-Tocopherol Stereoisomers in Human Plasma Are Affected by the Level and Form of the Vitamin E Supplement Used.  |  Zhao, Y., et al. 2015. J Nutr. 145: 2347-54. PMID: 26290004
  10. Association of serum γ-tocopherol levels with mortality: the Multiethnic Cohort Study.  |  Chai, W., et al. 2020. Eur J Clin Nutr. 74: 87-96. PMID: 31243335
  11. Gamma tocopherol, its dimmers, and quinones: Past and future trends.  |  Zheng, L., et al. 2020. Crit Rev Food Sci Nutr. 60: 3916-3930. PMID: 31957471
  12. Engineering of a functional γ-tocopherol transfer protein.  |  Aeschimann, W., et al. 2021. Redox Biol. 38: 101773. PMID: 33197771
  13. Gamma-tocopherol, a major form of vitamin E in diets: Insights into antioxidant and anti-inflammatory effects, mechanisms, and roles in disease management.  |  Jiang, Q., et al. 2022. Free Radic Biol Med. 178: 347-359. PMID: 34896589
  14. β-Glucosylceramides and Tocopherols Regulate Development and Function of Dendritic Cells.  |  Lajiness, JD., et al. 2022. J Immunol. 209: 1837-1850. PMID: 36426950

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

γ-Tocopherol, 5 mg

sc-213224
5 mg
$91.00