gamma Synuclein/SNCG Antibody (8H11): sc-135575
- gamma Synuclein/SNCG Antibody (8H11) is a mouse monoclonal IgG2a κ provided at 50 µg/0.5 ml
- raised against recombinant γ-synuclein protein of human origin
- recommended for detection of γ-synuclein of human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for gamma Synuclein/SNCG Antibody (8H11). This work is in progress.
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γ-synuclein Antibody (8H11) is a mouse monoclonal IgG2a antibody that detects γ-synuclein in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). γ-synuclein, also known as breast cancer-specific gene 1 (BCSG1), is a presynaptic protein predominantly expressed in the brain and is particularly important in the context of neurodegenerative diseases. γ-synuclein is primarily localized to the axonal compartments of neurons, where γ-synuclein plays a crucial role in synaptic function and neuronal communication. The localization of γ-synuclein is significant because γ-synuclein suggests a direct involvement in the regulation of neurotransmitter release and synaptic plasticity, processes that are vital for learning and memory. Furthermore, dysregulation of γ-synuclein has been implicated in the pathogenesis of Parkinson′s disease, where γ-synuclein is associated with axonal pathology, highlighting γ-synuclein′s potential as a biomarker for neurodegeneration. Anti-γ-synuclein antibody (8H11) is an essential tool for researchers investigating the molecular mechanisms underlying synaptic function and the role of synucleins in neurodegenerative disorders.
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gamma Synuclein/SNCG Antibody (8H11) References:
- beta-Synuclein reduces proteasomal inhibition by alpha-synuclein but not gamma-synuclein. | Snyder, H., et al. 2005. J Biol Chem. 280: 7562-9. PMID: 15591046
- Role of gamma-synuclein in microtubule regulation. | Zhang, H., et al. 2011. Exp Cell Res. 317: 1330-9. PMID: 20974125
- Defining the oligomerization state of γ-synuclein in solution and in cells. | Golebiewska, U., et al. 2014. Biochemistry. 53: 293-9. PMID: 24367999
- New α- and γ-synuclein immunopathological lesions in human brain. | Surgucheva, I., et al. 2014. Acta Neuropathol Commun. 2: 132. PMID: 25209836
- Gamma-synuclein pathology in amyotrophic lateral sclerosis. | Peters, OM., et al. 2015. Ann Clin Transl Neurol. 2: 29-37. PMID: 25642432
- [Expressions of TUBB3 and γ-synuclein in colorectal adenocarcinoma and their clinical significance]. | Sun, H., et al. 2015. Zhonghua Yi Xue Za Zhi. 95: 1242-4. PMID: 26081510
- Identification of gamma-synuclein as a new PCBP1-interacting protein. | Hunkele, A., et al. 2016. Neurol Res. 38: 1064-1078. PMID: 26344801
- Gamma-synuclein binds to AKT and promotes cancer cell survival and proliferation. | Ma, Z., et al. 2016. Tumour Biol. 37: 14999-15005. PMID: 27655287
- γ-Synuclein is Closely Involved in Autophagy that Protects Colon Cancer Cell from Endoplasmic Reticulum Stress. | Ye, Q., et al. 2021. Anticancer Agents Med Chem. 21: 2385-2396. PMID: 33463478
- Up and Down γ-Synuclein Transcription in Dopamine Neurons Translates into Changes in Dopamine Neurotransmission and Behavioral Performance in Mice. | Pavia-Collado, R., et al. 2022. Int J Mol Sci. 23: PMID: 35163729
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
gamma Synuclein/SNCG Antibody (8H11) | sc-135575 | 50 µg/0.5 ml | $333.00 |