Molecular structure of γ-Secretase Inhibitor XI
γ-Secretase Inhibitor XI
Alternate Names:
7-Amino-4-chloro-3-methoxyisocoumarin
Application:
γ-Secretase Inhibitor XI is a γ-secretase inhibitor useful in amyloid-β studies
Purity:
≥97%
Molecular Weight:
225.6
Molecular Formula:
C10H8ClNO3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
A cell-permeable, active site directed, irreversible serine protease inhibitor that belongs to the class of isocoumarin analogs. Acts as a potent and selective inhibitor of γ-secretase and blocks the production of both amyloid-β40 and Aβ42 in HEK293 cells expressing wild-type and Swedish-mutant β-amyloid precursor protein (APP).
γ-Secretase Inhibitor XI References
- New protease inhibitors prevent gamma-secretase-mediated production of Abeta40/42 without affecting Notch cleavage. | Petit, A., et al. 2001. Nat Cell Biol. 3: 507-11. PMID: 11331880
- Amyloid-lowering isocoumarins are not direct inhibitors of gamma-secretase. | Esler, WP., et al. 2002. Nat Cell Biol. 4: E110-1; author reply E111-2. PMID: 11988746
- Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis. | Hellström, M., et al. 2007. Nature. 445: 776-80. PMID: 17259973
- Isocoumarin-based inhibitors of pancreatic cholesterol esterase. | Heynekamp, JJ., et al. 2008. Bioorg Med Chem. 16: 5285-94. PMID: 18353652
- Reaction of porcine pancreatic elastase with 7-substituted 3-alkoxy-4-chloroisocoumarins: design of potent inhibitors using the crystal structure of the complex formed with 4-chloro-3-ethoxy-7-guanidinoisocoumarin. | Powers, JC., et al. 1990. Biochemistry. 29: 3108-18. PMID: 2337582
- Nonsteroidal anti-inflammatory drugs suppress cancer stem cells via inhibiting PTGS2 (cyclooxygenase 2) and NOTCH/HES1 and activating PPARG in colorectal cancer. | Moon, CM., et al. 2014. Int J Cancer. 134: 519-29. PMID: 23852449
- Stepwise Versus Concerted Mechanisms in General-Base Catalysis by Serine Proteases. | Uritsky, N., et al. 2016. Angew Chem Int Ed Engl. 55: 1680-4. PMID: 26691899
- A Review of Stapled Peptides and Small Molecules to Inhibit Protein-Protein Interactions in Cancer. | Iyer, VV. 2016. Curr Med Chem. 23: 3025-3043. PMID: 27356541
- Fluoxetine attenuates apoptosis in early brain injury after subarachnoid hemorrhage through Notch1/ASK1/p38 MAPK signaling pathway. | Liu, M., et al. 2022. Bioengineered. 13: 8396-8411. PMID: 35383529
- Reaction of serine proteases with substituted 3-alkoxy-4-chloroisocoumarins and 3-alkoxy-7-amino-4-chloroisocoumarins: new reactive mechanism-based inhibitors. | Harper, JW. and Powers, JC. 1985. Biochemistry. 24: 7200-13. PMID: 3910097
- Mechanism-based isocoumarin inhibitors for human leukocyte elastase. Effect of the 7-amino substituent and 3-alkoxy group in 3-alkoxy-7-amino-4-chloroisocoumarins on inhibitory potency. | Kerrigan, JE., et al. 1995. J Med Chem. 38: 544-52. PMID: 7853347
Inhibitor of:
Gamma-secretase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
γ-Secretase Inhibitor XI, 5 mg | sc-222305 | 5 mg | $218.00 |