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γ-Secretase Inhibitor III is a cell-permeable, reversible inhibitor of γ-secretase that reduces the formation of both Aβ total (IC50 ~ 35 μM) and Aβ1-42 using Chinese hamster ovary cultures stably transfected with Amyloid Precursor Protein-751. γ-Secretase Inhibitor III inhibits calpain (IC50 = 3 μM). It has been reported to be nontoxic and specific for γ-secretase.
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