Molecular structure of γ-Linolenic Acid (18:3, n-6), CAS Number: 506-26-3
γ-Linolenic Acid (18:3, n-6) (CAS 506-26-3)
See product citations (2)
Alternate Names:
gamolenic acid
Application:
γ-Linolenic Acid (18:3, n-6) is an antitumor agent
CAS Number:
506-26-3
Purity:
99%
Molecular Weight:
278.43
Molecular Formula:
C18H30O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
γ-Linolenic Acid (18:3, n-6) also known as gamma-Linolenic acid, is an unsaturated fatty acid synthesized from linoleic acid (LA) by the enzyme delta-6-desaturase. Research on hepatocellular cell lines has shown gamma-Linolenic Acid to have induced reactive oxygen species generation including lipid peroxidation, cell growth inhibition, and heme oxygenase-1 production for antioxidant protection against oxidative stress. Further experiments have noted that gamma-Linolenic acid inhibits inflammatory responses through inactivation of NFkappaB and activator protein-1 by suppressed oxidative stress.
γ-Linolenic Acid (18:3, n-6) (CAS 506-26-3) References
- Differential metabolism of dihomo-gamma-linolenic acid and arachidonic acid by cyclo-oxygenase-1 and cyclo-oxygenase-2: implications for cellular synthesis of prostaglandin E1 and prostaglandin E2. | Levin, G., et al. 2002. Biochem J. 365: 489-96. PMID: 11939906
- Gamma-linolenic acid dietary supplementation can reverse the aging influence on rat liver microsome delta 6-desaturase activity. | Biagi, PL., et al. 1991. Biochim Biophys Acta. 1083: 187-92. PMID: 1674661
- Gamma-linolenic acid inhibits inflammatory responses by regulating NF-kappaB and AP-1 activation in lipopolysaccharide-induced RAW 264.7 macrophages. | Chang, CS., et al. 2010. Inflammation. 33: 46-57. PMID: 19842026
- The use of alpha-lipoic acid (ALA), gamma linolenic acid (GLA) and rehabilitation in the treatment of back pain: effect on health-related quality of life. | Ranieri, M., et al. 2009. Int J Immunopathol Pharmacol. 22: 45-50. PMID: 19887043
- Modification of liver fatty acid metabolism in mice by n-3 and n-6 delta 6-desaturase substrates and products. | Huang, YS., et al. 1991. Biochim Biophys Acta. 1082: 319-27. PMID: 2029550
- Antineoplastic effects of gamma linolenic Acid on hepatocellular carcinoma cell lines. | Itoh, S., et al. 2010. J Clin Biochem Nutr. 47: 81-90. PMID: 20664735
- Functional characterization of a delta 6-desaturase gene from the black seabream (Acanthopagrus schlegeli). | Kim, SH., et al. 2011. Biotechnol Lett. 33: 1185-93. PMID: 21318631
- The effect of gamma-linolenic acid, an in vitro cytostatic substance contained in evening primrose oil, on primary liver cancer. A double-blind placebo controlled trial. | van der Merwe, CF., et al. 1990. Prostaglandins Leukot Essent Fatty Acids. 40: 199-202. PMID: 2169638
- High levels of stearic acid, palmitoleic acid, and dihomo-γ-linolenic acid and low levels of linoleic acid in serum cholesterol ester are associated with high insulin resistance. | Kurotani, K., et al. 2012. Nutr Res. 32: 669-675.e3. PMID: 23084639
- Antitumor effect of gamma-linolenic acid on cultured human neuroblastoma cells. | Fujiwara, F., et al. 1986. Prostaglandins Leukot Med. 23: 311-20. PMID: 3020590
- The effect of dihomo-gamma-linolenic acid (20: 3,n-6) on the composition of phospholipid fatty acids in the liver of rats deficient in essential fatty acids. | Hassam, AG. and Crawford,. 1978. Br J Nutr. 40: 155-7. PMID: 666999
- Effects of dietary gamma-linolenic acid on the tissue phospholipid fatty acid composition and the synthesis of eicosanoids in rats. | Quoc, KP. and Pascaud, M. 1996. Ann Nutr Metab. 40: 99-108. PMID: 8773734
- Fatty acyl desaturation in isolated hepatocytes from Atlantic salmon (Salmo salar): stimulation by dietary borage oil containing gamma-linolenic acid. | Tocher, DR., et al. 1997. Lipids. 32: 1237-47. PMID: 9438233
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
γ-Linolenic Acid (18:3, n-6), 100 mg | sc-200774 | 100 mg | $72.00 | |||
γ-Linolenic Acid (18:3, n-6), 1 g | sc-200774A | 1 g | $173.00 |