γ-CEHC (CAS 178167-75-4)
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γ-CEHC(Gamma-CEHC), a natural compound found in the catechol family, is present in various fruits and vegetables and is also synthesized by the liver and kidneys. This compound is recognized for its potent antioxidant properties and has been the focus of numerous studies due to its role in guarding against oxidative stress and inflammation. Research interest in γ-CEHC has surged, with investigations examining its capacity to combat oxidative damage and reduce inflammatory responses. Studies have also explored its potential impact on cardiovascular and neurodegenerative conditions. The antioxidative mechanism of γ-CEHC involves neutralizing free radicals and thus mitigating oxidative harm. Moreover, it boosts the levels of antioxidant enzymes like superoxide dismutase and catalase, fortifying the body′s defenses against oxidative stress. Additionally, it has demonstrated an ability to decrease inflammation by curbing the production of pro-inflammatory cytokines.
γ-CEHC (CAS 178167-75-4) References
- Alpha-tocopherol affects the urinary and biliary excretion of 2,7,8-trimethyl-2 (2'-carboxyethyl)-6-hydroxychroman, gamma-tocopherol metabolite, in rats. | Kiyose, C., et al. 2001. Lipids. 36: 467-72. PMID: 11432458
- Gas chromatography mass spectrometry analysis of carboxyethyl-hydroxychroman metabolites of alpha- and gamma-tocopherol in human plasma. | Galli, F., et al. 2002. Free Radic Biol Med. 32: 333-40. PMID: 11841923
- Tocopherol metabolites 2, 5, 7, 8-tetramethyl-2-(2'-carboxyethyl)-6-hydroxychroman (alpha-CEHC) and 2, 7, 8-trimethyl-2-(2'-carboxyethyl)-6-hydroxychroman (gamma-CEHC) in human serum after a single dose of natural vitamin E. | Radosavac, D., et al. 2002. Eur J Nutr. 41: 119-24. PMID: 12111049
- Accumulation of vitamin E metabolites in the blood of renal failure patients. | Galli, F., et al. 2004. Clin Nutr. 23: 205-12. PMID: 15030960
- Anti-inflammatory effects of tocopherol metabolites. | Grammas, P., et al. 2004. Biochem Biophys Res Commun. 319: 1047-52. PMID: 15184087
- Intravenous administration of 2,7,8-trimethyl-2-(beta-carboxyethyl)-6-hydroxy chroman (gamma-CEHC) to rats and determination of its plasma concentration and urinary sodium excretion. | Tanabe, M., et al. 2004. Biomed Chromatogr. 18: 727-34. PMID: 15386582
- First synthesis of rac-(5-2H3)-alpha-CEHC, a labeled analogue of a major vitamin E metabolite. | Mazzini, F., et al. 2004. J Org Chem. 69: 9303-6. PMID: 15609972
- A comparison between the antioxidant and peroxynitrite-scavenging functions of the vitamin E metabolites alpha- and gamma-carboxyethyl-6-hydroxychromans. | Galli, F., et al. 2004. Int J Vitam Nutr Res. 74: 362-73. PMID: 15628675
- Alpha-tocopherol modulates Cyp3a expression, increases gamma-CEHC production, and limits tissue gamma-tocopherol accumulation in mice fed high gamma-tocopherol diets. | Traber, MG., et al. 2005. Free Radic Biol Med. 38: 773-85. PMID: 15721988
- Quantitation of rat liver vitamin E metabolites by LC-MS during high-dose vitamin E administration. | Leonard, SW., et al. 2005. J Lipid Res. 46: 1068-75. PMID: 15722564
- The coantioxidative effects of carboxyethyl-6-hydroxychromans and alpha-Tocopherol. | Uto-Kondo, H., et al. 2007. J Nutr Sci Vitaminol (Tokyo). 53: 301-5. PMID: 17934234
- Plasma phospholipase, γ-CEHC and antioxidant capacity in fibromyalgia. | Fais, A., et al. 2017. Int J Rheum Dis. 20: 550-554. PMID: 26585319
- Associations of 24 h urinary excretions of α- and γ-carboxyethyl hydroxychroman with plasma α- and γ-tocopherol and dietary vitamin E intake in older adults: the Lifelines-MINUTHE Study. | Zhu, Y., et al. 2022. Eur J Nutr. 61: 3755-3765. PMID: 35718823
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
γ-CEHC, 1 mg | sc-223880 | 1 mg | $45.00 | |||
γ-CEHC, 5 mg | sc-223880A | 5 mg | $198.00 |