Date published: 2025-10-14

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γ-Caprolactone (CAS 695-06-7)

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Alternate Names:
γ-Ethyl-γ-butyrolactone, gamma-Caprolactone
CAS Number:
695-06-7
Purity:
98%
Molecular Weight:
114.14
Molecular Formula:
C6H10O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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γ-Caprolactone is a versatile and important chemical used in various applications. Derived from caproic acid, a six-carbon fatty acid, γ-Caprolactone exists as a colorless, odorless, and water-soluble liquid. Its diverse utility ranges from serving as a monomer in polymer synthesis to functioning as an intermediate and as a solvent in chemical reactions. Moreover, it has found extensive use in scientific research, both in vivo and in vitro studies. Despite its wide usage, the exact mechanism of action for γ-Caprolactone remains incompletely understood. Nevertheless, it is believed to function as an agonist for several G protein-coupled receptors, including the G-protein coupled receptor GPR55. Additionally, gamma-Caprolactone has demonstrated interactions with the cannabinoid receptors CB1 and CB2. γ-Caprolactone is a valuable chemical compound with multiple applications and has played a significant role in numerous scientific research endeavors. Its potential as an agent in various receptor interactions further underscores its importance in the realm of scientific exploration.


γ-Caprolactone (CAS 695-06-7) References

  1. Growth promotion of quorum-quenching bacteria in the rhizosphere of Solanum tuberosum.  |  Cirou, A., et al. 2007. Environ Microbiol. 9: 1511-22. PMID: 17504488
  2. Gamma-caprolactone stimulates growth of quorum-quenching Rhodococcus populations in a large-scale hydroponic system for culturing Solanum tuberosum.  |  Cirou, A., et al. 2011. Res Microbiol. 162: 945-50. PMID: 21288487
  3. Catabolic pathway of gamma-caprolactone in the biocontrol agent Rhodococcus erythropolis.  |  Barbey, C., et al. 2012. J Proteome Res. 11: 206-16. PMID: 22085026
  4. A metagenomic study highlights phylogenetic proximity of quorum-quenching and xenobiotic-degrading amidases of the AS-family.  |  Tannières, M., et al. 2013. PLoS One. 8: e65473. PMID: 23762380
  5. Biofouling control by biostimulation of quorum-quenching bacteria in a membrane bioreactor for wastewater treatment.  |  Yu, H., et al. 2016. Biotechnol Bioeng. 113: 2624-2632. PMID: 27345371
  6. Local order and vibrational coupling of the C=O Stretching Mode of γ-Caprolactone in liquid binary mixtures.  |  Xu, W., et al. 2017. Sci Rep. 7: 12182. PMID: 28939813
  7. A Flavor Lactone Mimicking AHL Quorum-Sensing Signals Exploits the Broad Affinity of the QsdR Regulator to Stimulate Transcription of the Rhodococcal qsd Operon Involved in Quorum-Quenching and Biocontrol Activities.  |  Chane, A., et al. 2019. Front Microbiol. 10: 786. PMID: 31040836
  8. Vibrational Circular Dichroism study of chiral food additives: γ-valero- and γ-caprolactone.  |  Sánchez Valera, M., et al. 2021. Spectrochim Acta A Mol Biomol Spectrosc. 247: 119140. PMID: 33188971
  9. Profiling of Primary Metabolites and Volatile Determinants in Mahlab Cherry (Prunus mahaleb L.) Seeds in the Context of Its Different Varieties and Roasting as Analyzed Using Chemometric Tools.  |  Farag, MA., et al. 2021. Foods. 10: PMID: 33808142
  10. Efficient biostimulants for bacterial quorum quenching to control fouling in MBR.  |  Yu, H., et al. 2022. Chemosphere. 286: 131689. PMID: 34352546
  11. Product study of the reactions of γ-caprolactone and γ-heptalactone initiated by OH radicals at 298 K and atmospheric pressure: Formation of acyl peroxynitrates (APN).  |  Baptista, A., et al. 2023. Chemosphere. 323: 138156. PMID: 36796523

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

γ-Caprolactone, 25 g

sc-251458
25 g
$29.00