Gamithromycin (CAS 145435-72-9)
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Gamithromycin is a macrocyclic lactone of the azalide subclass, related to better-known macrolides, and it holds significant interest in biochemical and environmental research due to its structural complexity and binding affinity to bacterial ribosomes. In biochemical studies, gamithromycin is often used as a probe to understand the intricate process of protein synthesis inhibition, providing insights into the fundamental interactions between macrolide structures and the peptidyl transferase center of bacterial ribosomes. Environmental scientists study the compound′s biodegradability and its potential effects on microbial communities, especially in terms of resistance gene proliferation. Additionally, the compound serves as a model to explore the molecular underpinnings that define the activity spectrum of macrolides, aiding in the synthesis of novel compounds with specific target actions.
Gamithromycin (CAS 145435-72-9) References
- Pharmacokinetics of gamithromycin in cattle with comparison of plasma and lung tissue concentrations and plasma antibacterial activity. | Huang, RA., et al. 2010. J Vet Pharmacol Ther. 33: 227-37. PMID: 20557439
- In vitro pharmacodynamics of gamithromycin against Mycoplasma mycoides subspecies mycoides Small Colony. | Mitchell, JD., et al. 2013. Vet J. 197: 806-11. PMID: 23810743
- Pharmacokinetics of gamithromycin after intravenous and subcutaneous administration in pigs. | Wyns, H., et al. 2014. Res Vet Sci. 96: 160-3. PMID: 24331716
- Gamithromycin plasma and skin pharmacokinetics in sheep. | Kellermann, M., et al. 2014. Res Vet Sci. 97: 199-203. PMID: 25241389
- Pharmacokinetics and pulmonary distribution of gamithromycin after intravenous administration in foals. | Berlin, S., et al. 2017. J Vet Pharmacol Ther. 40: 406-410. PMID: 28317153
- Determination of gamithromycin in an injection by ultra-performance liquid chromatography-tandem quadrupole-time-of-flight mass spectrometry. | Wu, JX., et al. 2016. Pharmazie. 71: 378-381. PMID: 29441912
- Pharmacokinetics and Pharmacodynamics of Gamithromycin Treatment of Pasteurella multocida in a Murine Lung Infection Model. | Yang, Q., et al. 2019. Front Pharmacol. 10: 1090. PMID: 31680940
- Bordetella bronchiseptica experimental model development in pigs and efficacy evaluation of a single intramuscular injection of gamithromycin (Zactran® for Swine) against Bordetella bronchiseptica-associated respiratory disease in experimentally infected piglets. | Gupta, A., et al. 2020. J Vet Pharmacol Ther. 43: 197-207. PMID: 31872885
- Gamithromycin in swine: Pharmacokinetics and clinical evaluation against swine respiratory disease. | Hamel, D., et al. 2021. Vet Med Sci. 7: 455-464. PMID: 33058489
- Increased Antimicrobial Activity of Colistin in Combination With Gamithromycin Against Pasteurella multocida in a Neutropenic Murine Lung Infection Model. | Li, Y., et al. 2020. Front Microbiol. 11: 511356. PMID: 33072002
- Gamithromycin in sheep: Pharmacokinetics and clinical evaluation against ovine footrot. | Hamel, D., et al. 2021. Res Vet Sci. 142: 94-100. PMID: 34883297
- Plasma pharmacokinetics, pulmonary disposition, and safety of subcutaneous gamithromycin in alpacas. | Gordon, E., et al. 2022. J Vet Pharmacol Ther. 45: 283-290. PMID: 35170771
- Pharmacodynamic Target Assessment and PK/PD Cutoff Determination for Gamithromycin Against Streptococcus suis in Piglets. | Wang, RL., et al. 2022. Front Vet Sci. 9: 945632. PMID: 35898553
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Gamithromycin, 1 mg | sc-489549 | 1 mg | $265.00 |