Gambogic amide (CAS 286935-60-2)
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Gambogic amide is an analog of gambogic acid, which is a product found in the resin of Garcinia hanburyi. In research, gambogic amide is extensively studied for its potential biological activities, including its ability to interact with various proteins involved in cellular signaling pathways. It is a compound of research interest for its role in modulating apoptosis, particularly through the induction of cell death in certain types of cancer cells in vitro. Researchers employ gambogic amide to investigate its effects on the regulation of transcription factors and the potential disruption of protein-protein interactions within cells. Additionally, it is used to study its influence on the cell cycle and its potential as a modulator of proteasome activity. The compound′s capacity to induce oxidative stress is another avenue of research, contributing to the understanding of the cellular response to oxidative damage.
Gambogic amide (CAS 286935-60-2) References
- Gambogic amide, a selective agonist for TrkA receptor that possesses robust neurotrophic activity, prevents neuronal cell death. | Jang, SW., et al. 2007. Proc Natl Acad Sci U S A. 104: 16329-34. PMID: 17911251
- NGF inhibits human leukemia proliferation by downregulating cyclin A1 expression through promoting acinus/CtBP2 association. | Chan, CB., et al. 2009. Oncogene. 28: 3825-36. PMID: 19668232
- Kinomic profiling approach identifies Trk as a novel radiation modulator. | Jarboe, JS., et al. 2012. Radiother Oncol. 103: 380-7. PMID: 22561027
- Novel small molecule activators of the Trk family of receptor tyrosine kinases. | Obianyo, O. and Ye, K. 2013. Biochim Biophys Acta. 1834: 2213-8. PMID: 22982231
- Inhibition of neuronal apoptosis and axonal regression ameliorates sympathetic atrophy and hemodynamic alterations in portal hypertensive rats. | Ezkurdia, N., et al. 2014. PLoS One. 9: e84374. PMID: 24400086
- Gambogic amide selectively upregulates TrkA expression and triggers its activation. | Shen, J. and Yu, Q. 2015. Pharmacol Rep. 67: 217-23. PMID: 25712642
- Distinct TrkA and Ret modulated negative and positive neuropathic behaviors in a mouse model of resiniferatoxin-induced small fiber neuropathy. | Hsieh, YL., et al. 2018. Exp Neurol. 300: 87-99. PMID: 29106982
- Gambogic amide, a selective TrkA agonist, does not improve outcomes from traumatic brain injury in mice. | Johnstone, MR., et al. 2018. Brain Inj. 32: 257-268. PMID: 29227174
- The selective TrkA agonist, gambogic amide, promotes osteoblastic differentiation and improves fracture healing in mice. | Johnstone, MR., et al. 2019. J Musculoskelet Neuronal Interact. 19: 94-103. PMID: 30839307
- Effects of the selective TrkA agonist gambogic amide on pigmentation and growth of human hair follicles in vitro. | Campiche, R., et al. 2019. PLoS One. 14: e0221757. PMID: 31465471
- Effects of in-vitro modulation of TRPV1 activity on immune response of mice bearing metastatic breast carcinoma: Enhanced inflammatory response may hinder therapeutic potentials of TRPV1 agonists. | Erin, N. and Akman, M. 2021. Life Sci. 287: 120115. PMID: 34740578
- Gambogic amide inhibits angiogenesis by suppressing VEGF/VEGFR2 in endothelial cells in a TrkA-independent manner. | Sui, T., et al. 2021. Pharm Biol. 59: 1566-1575. PMID: 34767490
- TrkA+ Neurons Induce Pathologic Regeneration After Soft Tissue Trauma. | Cherief, M., et al. 2022. Stem Cells Transl Med. 11: 1165-1176. PMID: 36222619
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Gambogic amide, 1 mg | sc-221655 | 1 mg | $173.00 | |||
Gambogic amide, 5 mg | sc-221655A | 5 mg | $607.00 |