Molecular structure of Gallein, CAS Number: 2103-64-2
Gallein (CAS 2103-64-2)
See product citations (20)
Alternate Names:
Mordant Violet 25; Alizarin Violet; 3′,4′,5′,6′-Tetrahydroxyspiro[isobenzofuran-1(3H),9′-(9H)xanthen]-3-one
Application:
Gallein is an inhibitor of Gβγ-dependent cellular activities which binds to Gβγ with high affinity
CAS Number:
2103-64-2
Molecular Weight:
364.31
Molecular Formula:
C20H12O7
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Gallein is a cell-permeable xanthene compound that binds to Gbetagamma with high affinity (Kd ~400 nM derived from a surface plasma resonance binding study using Gbeta1gamma2) and blocks Gbetagamma-dependent cellular activities. Gallein is reported to exhibit prophylactic efficacy against carrageenan-induced neutrophil recruitment and tissue swelling in a murine paw edema model. Gallein is an inhibitor of G beta and G gamma. It binds to G beta and G gamma with high affinity and blocks their activities. Gallein may act to be effective in preventing inflammation and tissue swelling in a mouse paw edema model.
Gallein (CAS 2103-64-2) References
- G-protein βγ subunits in vasorelaxing and anti-endothelinergic effects of calcitonin gene-related peptide. | Meens, MJ., et al. 2012. Br J Pharmacol. 166: 297-308. PMID: 22074193
- Simultaneous adrenal and cardiac g-protein-coupled receptor-gβγ inhibition halts heart failure progression. | Kamal, FA., et al. 2014. J Am Coll Cardiol. 63: 2549-2557. PMID: 24703913
- Inhibition of G Protein βγ Subunit Signaling Abrogates Nephritis in Lupus-Prone Mice. | Rangel-Moreno, J., et al. 2016. Arthritis Rheumatol. 68: 2244-56. PMID: 26990948
- Histamine 1 receptor-Gβγ-cAMP/PKA-CFTR pathway mediates the histamine-induced resetting of the suprachiasmatic circadian clock. | Kim, YS., et al. 2016. Mol Brain. 9: 49. PMID: 27153809
- Gallein, a Gβγ subunit signalling inhibitor, inhibits metastatic spread of tumour cells expressing OR51E2 and exposed to its odorant ligand. | Sanz, G., et al. 2017. BMC Res Notes. 10: 541. PMID: 29084601
- Gαi and Gβγ subunits have opposing effects on dexmedetomidine-induced sedation. | Liu, M., et al. 2018. Eur J Pharmacol. 831: 28-37. PMID: 29738700
- Investigating the Role of G Protein βγ in Kv7-Dependent Relaxations of the Rat Vasculature. | Stott, JB., et al. 2018. Arterioscler Thromb Vasc Biol. 38: 2091-2102. PMID: 30002060
- Small molecule disruption of G protein βγ subunit signaling reprograms human macrophage phenotype and prevents autoimmune myocarditis in rats. | Karuppagounder, V., et al. 2018. PLoS One. 13: e0200697. PMID: 30024944
- Development of Inflammatory Immune Response-Related Drugs Based on G Protein-Coupled Receptor Kinase 2. | Han, C., et al. 2018. Cell Physiol Biochem. 51: 729-745. PMID: 30463058
- The G-protein βγ subunits regulate platelet function. | Alarabi, AB., et al. 2020. Life Sci. 262: 118481. PMID: 32971104
- A Dual-Specificity Inhibitor Targets Polyphosphate Kinase 1 and 2 Enzymes To Attenuate Virulence of Pseudomonas aeruginosa. | Neville, N., et al. 2021. mBio. 12: e0059221. PMID: 34126765
- Improving Photocatalytic Hydrogen Production through Incorporating Copper to Organic Photosensitizers. | Chen, Y., et al. 2022. Inorg Chem. 61: 12545-12551. PMID: 35926191
- Fluoride and gallein inhibit polyphosphate accumulation by oral pathogen Rothia dentocariosa. | Kumar, D., et al. 2023. Lett Appl Microbiol. 76: PMID: 36715153
- Gβγ signaling regulates microtubule-dependent control of Golgi integrity. | Rajanala, K. and Wedegaertner, PB. 2023. Cell Signal. 106: 110630. PMID: 36805843
Inhibitor of:
Centrin-4, Dear, G beta, Gα 15, Gα i-1, Gα o, Gβ 3, Gβ 5, Gγ 10, Gγ 11, Gγ 13, Gγ 9, GAIP, Gm14496, GPA-16, Gpa2, GPR144, GRK 6, IP3R-I, MrgB8, Olfr1008, Olfr1015, Olfr1037, Olfr1051, Olfr1061, Olfr1079, Olfr1093, Olfr1115, Olfr438, Olfr448, Olfr493, Olfr498, Olfr5, Olfr50, Olfr502, Olfr503, Olfr51, Olfr651, Olfr704, Olfr705, Olfr706, Olfr707, Olfr708, Olfr71, Olfr710, Olfr711, Olfr716, Olfr776, Olfr777, Olfr780, Olfr787, Olfr816, Olfr818, Olfr862, Olfr866, Olfr867, Olfr868, Olfr871, Olfr872, Olfr874, Olfr890, Olfr891, Olfr893, Olfr894, Olfr895, Olfr898, Olfr899, Olfr923, Olfr924, Olfr926, Olfr93, OPN1MW2, OR1S2, OR4D10, RAPGEF6, Regulator of G protein signaling (RGS), RGS1, RGS14, RGS17, RGS22, RGS8, SSTR3, Ste4, V1rc31, Vmn1r12, and Vmn1r20.Activator of:
ARHGEF17, Gγ 1, GRIN3, GRK 1, Lfc, Olfr544, ORNT1, ORNT2, RGS11, and RGS6.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Gallein, 50 mg | sc-202631 | 50 mg | $83.00 |