Dieser polyklonale Antikörper wird nicht mehr hergestellt. Wir empfehlen Ihnen unseren GADD 45β (G-11) monoklonalen Antikörper (Beispielsdaten werden angezeigt).
GADD 45β Antikörper (C-18): sc-8776
- GADD 45 beta Antikörper C-18 ist ein polyklonales IgG aus der Ziege in einer Menge von 200 µg/ml
- das Epitop liegt am C-terminus von GADD 45β aus der Spezies human
- Nicht länger erhältlicher polyklonaler Antikörper
Cell cycle progression is subject to arrest at G1 and G2 checkpoints in response to DNA damage, presumably to allow time for DNA repair prior to entry into S and M phase, respectively. The p53 tumor suppressor is required for one such G1 checkpoint and functions to upregulate expression of GADD 45 and p21. GADD 45 binds both Cdks and PCNA, a protein involved in DNA replication and repair. GADD 45 stimulates DNA excision repair in vitro and in hibits entry of cells into S phase. Thus, it has been suggested that GADD 45 may serve as a link between the p53-dependent cell cycle checkpoint and DNA repair. GADD 45-like proteins, GADD 45β and GADD 45γ, have been shown to be induced by environmental stresses. GADD 45β and GADD 45γ are thought to induce p38/JNK activation via MEKK4 activation.
Bestellinformation
GADD 45β (G-11): sc-377311 [ Empfohlener monoklonaler Ersatz für GADD 45β (C-18) ]
| Produkt | Katalog # | EINHEIT | Preis | ANZAHL | Favoriten | |
GADD 45β Antikörper (G-11) | sc-377311 | 200 µg/ml | $322.00 | |||
GADD 45β (G-11) Neutralizing Peptid | sc-377311 P | 100 µg/0.5 ml | $69.00 |